Results 51 to 60 of about 315,105 (310)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Assessing Myocardial Strain and Myocardial Work as a Marker for Hypertensive Heart Disease: A Meta-Analysis

Reviews in Cardiovascular Medicine, 2023
Background: The main objective of this study was to determine whether myocardial strain and myocardial work are altered in hypertension and whether the strain is independent of hypertension-induced left ventricular hypertrophy.
Simon W. Rabkin
doaj   +1 more source

Usefulness of regional right ventricular and right atrial strain for prediction of early and late right ventricular failure following a left ventricular assist device implant: A machine learning approach [PDF]

, 2019
Background: Identifying candidates for left ventricular assist device surgery at risk of right ventricular failure remains difficult. The aim was to identify the most accurate predictors of right ventricular failure among clinical, biological, and ...
Agnese V., Bellavia D., Clemenza F., Coronnello C., di Gesaro G., Falletta C., Gorcsan S. J., Iacovoni A., Maalouf J., Novo G., Pasta S., Pilato M., Sciacca S., Senni M., Simon M.   +14 more
core   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Speckle-Tracking echocardiography to assess global and regional left ventricular function in acute myocardial infarction

Journal of the Indian Academy of Echocardiography & Cardiovascular Imaging, 2017
Speckle tracking is a useful tool in assessing global & regional myocardial function in patients with acute myocardial infarction undergoing primary PCI.
Gopi Aniyathodiyil, Sunil S Bohra, Anup Mottengar, Satish C Govind   +3 more
doaj   +1 more source

Multilayer vs. global 2D-longitudinal strain in hypertrophic cardiomyopathy.

Archives of Cardiovascular Diseases Supplements, 2018
Introduction Hypertrophic cardiomyopathy (HCM) is a genetic heart disease defined by structural and functional abnormalities of the myocardium. HCM is characterized by systolic and diastolic dysfunction with major complications: sudden cardiac death and terminal heart failure. Altered left ventricular global longitudinal strain (LV GLS) is known to be
A. Coppin, A. Duva Pentiah, A. Coisne, H. Ridon, S. Mouton, P. De Groote, D. Montaigne   +6 more
openaire   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Evaluation of right ventricular function performed by 3d-echocardiography in scleroderma patients [PDF]

, 2015
The impairment of the right ventricle (RV) in systemic sclerosis (SSc) is usually related to pulmonary arterial hypertension (PAH). New echocardiographic techniques, such as 3-dimensional echocardiography (3DE) and 2-dimensional speckle tracking (2DSTE),
Badano, Luigi, Bourji, KHALIL IBRAHIM, Cozzi, Franco, Miatton, P., Peluso, DILETTA MARIA, Pigatto, Erika, Polito, Pamela, Punzi, Leonardo, Zanatta, E.   +8 more
core   +2 more sources

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento, Daniela F. Santos, Tuane C. R. G. Vieira, Tiago F. Outeiro   +3 more
wiley   +1 more source

Assessment of new-onset heart failure prediction in a diabetic population using left ventricular global strain: a prospective cohort study based on UK Biobank

Frontiers in Endocrinology
BackgroundImpaired glucose utilization influences myocardial contractile function. However, the prognostic importance of left ventricular global radial strain (LV-GRS), left ventricular global circumferential strain (LV-GCS), and left ventricular global ...
Siwei Chen, Cong Chen, Longxuan Zheng, Wenke Cheng, Xiancong Bu, Zhou Liu   +5 more
doaj   +1 more source