Results 51 to 60 of about 7,037,374 (298)

Assessing Myocardial Strain and Myocardial Work as a Marker for Hypertensive Heart Disease: A Meta-Analysis

Reviews in Cardiovascular Medicine, 2023
Background: The main objective of this study was to determine whether myocardial strain and myocardial work are altered in hypertension and whether the strain is independent of hypertension-induced left ventricular hypertrophy.
Simon W. Rabkin
doaj   +1 more source

Global longitudinal strain in acute myocardial infarction and incidence of in-hospital heart failure.

, 2022
BACKGROUND: Myocardial strain is a good prognostic factor independent of ejection fraction for outcomes in heart failure. We evaluated the prognostic role of global longitudinal strain in acute myocardial infarction to identify the likelihood of in ...
Rania Abdelhady, Ebeid, Hassan, Khaled Ahmed Elkhashab, Elkhashab, Khaled Ahmed, Mohamed Osama Hussein, Hassan Ebeid, Ghareeb, Haytham Soliman, Abdelhady, Rania, Hussein, Mohamed Osama, Haytham Soliman Ghareeb   +9 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Reproducibility of left ventricular global longitudinal strain using two-dimensional ultrasound speckle tracking : Longitudinal Study of Adult Health (ELSA-Brasil) [PDF]

, 2018
Introducción Se han propuesto técnicas ecocardiográficas avanzadas como el strain longitudinal global por ecocardiografía bidimensional speckle tracking para la detección de alteraciones precoces de la función sistólica del ventrículo izquierdo.
Nunes, Lisandra Almeida, Foppa, Murilo, Santos, Ângela Barreto Santiago, Cañon-Montañez, Wilson, Duncan, Bruce Bartholow, Schmidt, Maria Inês, Amaral, Maria Vitória França do   +6 more
core   +1 more source

Association between angiopoietin‐2 and functional cardiac remodeling in hemodialysis patients with normal left ventricular ejection

The Journal of Clinical Hypertension, 2022
Cardiac remodeling is the initial process in heart failure development. The aim of this study is to evaluate the association between endothelium‐related biomarkers and cardiac remodeling in hemodialysis (HD) patients and how the presence of high blood ...
Ana Aécia Alexandrino deOliveira, Thaís Alexandrino deOliveira, Larissa Alexandrino deOliveira, Gdayllon Cavalcante Meneses, Gabriela Freire Bezerra, Alice Maria Costa Martins, Alexandre Braga Libório   +6 more
doaj   +1 more source

Longitudinal Speckle Tracking Strain Abnormalities in Chagas Disease: A Systematic Review and Meta-Analysis. [PDF]

, 2022
BACKGROUND Chronic Chagas cardiomyopathy (CCM) is ranked among heart failure etiologies with the highest mortality rates. CCM is characterized by alterations in left ventricular function with a typical and unique pattern of myocardial involvement ...
Muka, Taulant, Sergio Alejandro Gómez-Ochoa, Taulant Muka, Rojas, Lyda Z, Jorge Largo, Echeverría, Luis E, Lyda Z. Rojas, Hernández-Vargas, Juliana Alexandra, Gómez-Ochoa, Sergio Alejandro, Largo, Jorge, Juliana Alexandra Hernández-Vargas, Luis E. Echeverría   +11 more
core   +2 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Assessment of new-onset heart failure prediction in a diabetic population using left ventricular global strain: a prospective cohort study based on UK Biobank

Frontiers in Endocrinology
BackgroundImpaired glucose utilization influences myocardial contractile function. However, the prognostic importance of left ventricular global radial strain (LV-GRS), left ventricular global circumferential strain (LV-GCS), and left ventricular global ...
Siwei Chen, Cong Chen, Longxuan Zheng, Wenke Cheng, Xiancong Bu, Zhou Liu   +5 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source