Results 91 to 100 of about 57,808 (284)
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Built-Up Area Change Analysis in Iasi City Using GIS
Present Environment and Sustainable Development, 2016 The study analyses the spatial and temporal changes occurred in the builtup area of Iași city and its surrounding areas using cartographic materials from different time periods.
Ursu Adrian +3 more
doaj +1 more source
A Framework for Genetic Algorithms Based on Hadoop
, 2013 Genetic Algorithms (GAs) are powerful metaheuristic techniques mostly used in many real-world applications. The sequential execution of GAs requires considerable computational power both in time and resources. Nevertheless, GAs are naturally parallel and
Ferrucci, F +4 more
core
Shouji: A Fast and Efficient Pre-Alignment Filter for Sequence Alignment
, 2019 Motivation: The ability to generate massive amounts of sequencing data continues to overwhelm the processing capability of existing algorithms and compute infrastructures.
Alkan, Can +4 more
core +2 more sources
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Teaching Statistics at Google Scale
, 2015 Modern data and applications pose very different challenges from those of the 1950s or even the 1980s. Students contemplating a career in statistics or data science need to have the tools to tackle problems involving massive, heavy-tailed data, often ...
Chamandy, Nicholas +2 more
core +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Remote Sensing, 2014 Stand age distribution is an important descriptor of boreal forest structure, which is directly linked to many ecosystem processes including the carbon cycle, the land–atmosphere interaction and ecosystem services, among others.
Dong Chen +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Dianci bileiqi, 2012 输电线路防雷实践需要全面准确地积累各种雷电参数及对输电线路线径周围地形地貌做出准确地判断,传统方法对雷电参数的积累不够全面和精确,而对输电线路周围地形地貌的判别往往需要耗费大量的人力物力。针对上述问题,简要介绍了Global Mapper软件的基本功能,重点阐述了该软件在输电线路雷电参数的优化统计和对雷击跳闸线路周围地形判别方面的应用。通过该软件,可以实现三维雷击地闪点定位,在三维地理空间更为全面地收集雷电参数;优化雷电地闪密度参数的计算方法,使雷电参数的统计更为精确;生成输电线路路径断面图 ...
申元, 王磊, 马御棠, 黄然
doaj