Results 101 to 110 of about 57,808 (284)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Watershed Analysis and Risk Assessment Using Global Mapper

GEOmedia
Watershed analysis provides critical insights into the natural flow of water across landscapes, helping to identify environmental risks and inform land-use and infrastructure planning.
Jenna Nelson
doaj  

Aplicación de SIG para la caracterización hidrogeológica de sistemas dunares (Erg Chebbi, Marruecos)

Estudios Geográficos, 2014
Los estudios hidrogeológicos en áreas desérticas de difícil acceso resultan logísticamente complicados. Sin embargo, en algunas de estas zonas el aprovechamineto de los recursos hídricos subterráneos resulta esencial para la supervivencia de las ...
Manuel García-Rodríguez, Loreto Antón
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Guía práctica para generar y mejorar topografías satelitales con el software “Global Mapper” enfocado al diseño vial

, 2023
La comunidad académica de la carrera de ingeniería civil, al generar y obtener topografías satelitales para proyectos viales desconocen de herramientas, materiales de apoyo que brindan cierto tipo de solución, este hecho confirma que se desaprovecha el software Global Mapper por desconocimiento.
Gualotuña Topón, Marilyn Carolina, Tituaña Chicaiza, Johnny David   +1 more
openaire   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Using the Cluster Analysis to Classify the Quality of Ground Water in Wells of Bashiqa Region in Governorate of Ninaveh [PDF]

المجلة العراقية للعلوم الاحصائية, 2012
استخدم في هذه الدراسة التحليل العنقودي لتصنيف (24) بئراً في المكمن المائي المتواجد ضمن التكوين بلاسبي في منطقة (بعشيقة) بالاعتماد على نوعية المياه الجوفيّة فيها لتحديد فيما إذا كانت عينات نوعية المياه في المواقع المختلفة يمكن ضمها إلى مناطق متجانسة, إذ ...
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Classification of groundwater type, pilaspi quality by using Kohonen neural network [PDF]

المجلة العراقية للعلوم الاحصائية, 2011
In this research, classification of(24) wells in the aquifer of water existed within the Pilaspi Geology Formation in the Bashiqa area ‎/ North of Mosul, by using one of the types of artificial neural networks and specifically (kohonen network(,by ...
doaj   +1 more source