Results 31 to 40 of about 7,971,883 (292)

The impact of diagnosis delay on European patients with generalised myasthenia gravis

Annals of Clinical and Translational Neurology
Objective The objective was to determine the mean duration of diagnosis delay for patients with myasthenia gravis from five European countries and explore the impact of >1 year diagnosis delay.
Elena Cortés‐Vicente, Andras J. Borsi, Charlotte Gary, Wim G.J. Noel, Jennifer M.S. Lee, Wisam Karmous, Qiaoyi Zhang, Kavita H. Gandhi, Alberto E. Batista, Jonathan J. DeCourcy, Sophie G. Barlow, Shiva L. Birija, Gregor A. Gibson   +12 more
doaj   +1 more source

Financial investments in the global water market [PDF]

, 2022
This chapter examines the relationship between the water sector of the equity markets. It includes the world market and markets of different individual countries such as China, Hong Kong, Singapore, Germany, France, the UK, Brazil, Chile, and the US for ...
Reza, R, Tularam, GA
core   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Efficacy and Safety of 4.7 mg Deslorelin Acetate Implants in Suppressing Oestrus Cycle in Prepubertal Female Dogs

Animals, 2022
Our multicentric, masked, controlled and randomised study aimed to assess the efficacy and safety of Suprelorin® 4.7 mg (Virbac, Carros, France) regarding oestrus prevention in prepubertal intact bitches.
Aymeric Gontier, Myriam Youala, Christelle Fontaine, Elsa Raibon, Sandrine Fournel, Philippe Briantais, Delphine Rigaut   +6 more
doaj   +1 more source

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

Pathways to, and use of, sexual healthcare among Black Caribbean sexual health clinic attendees in England: evidence from cross-sectional bio-behavioural surveys

BMC Health Services Research, 2019
Background In England, people of Black Caribbean (BC) ethnicity are disproportionately affected by sexually transmitted infections (STI). We examined whether differences in sexual healthcare behaviours contribute to these inequalities.
Catherine R. H. Aicken, Sonali Wayal, Paula B. Blomquist, Stella M. Fabiane, Makeda Gerressu, Gwenda Hughes, Catherine H. Mercer   +6 more
doaj   +1 more source

Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito, Kamal Benguerba, Ken Tsuchida, Kazushige Yazawa, Isao Tsumiyama, Hiromitsu Kayama, Sandra P. Reyna, Farid Khan, Richard S. Finkel   +8 more
wiley   +1 more source

Clinical burden of invasive Escherichia coli disease among older adult patients treated in hospitals in the United States

BMC Infectious Diseases, 2023
Background Invasive extraintestinal pathogenic Escherichia coli disease (IED) can lead to severe outcomes, particularly among older adults. However, the clinical burden of IED in the U.S. has not been well characterized.
Luis Hernandez-Pastor, Jeroen Geurtsen, Bryan Baugh, Antoine C. El Khoury, Nnanya Kalu, Marjolaine Gauthier-Loiselle, Rebecca Bungay, Martin Cloutier, Michal Sarnecki, Elie Saade   +9 more
doaj   +1 more source

Safety of Prescription Nonsteroidal Anti‐inflammatory Drugs in Adults With Inflammatory Bowel Disease: Data From a Large Administrative Claims Cohort

Arthritis Care &Research, EarlyView.
Objective The concern that nonsteroidal anti‐inflammatory drugs (NSAIDs) may precipitate flares of inflammatory bowel disease (IBD) has limited their use in managing musculoskeletal symptoms in those with IBD, but safety data are mixed. Methods This retrospective cohort study included patients with IBD aged at least 18 years from Optum's deidentified ...
Adam S. Mayer, Rui Xiao, Meenakshi Bewtra, Michael D. George, Pamela F. Weiss   +4 more
wiley   +1 more source

Exploring the feasibility of using the ICER Evidence Rating Matrix for Comparative Clinical Effectiveness in assessing treatment benefit and certainty in the clinical evidence on orphan therapies for paediatric indications

Orphanet Journal of Rare Diseases, 2023
Background The evaluation of clinical evidence takes account of health benefit (efficacy and safety) and the degree of certainty in the estimate of benefit.
Jaro Wex, Monika Szkultecka-Debek, Mariola Drozd, Sarah King, Natasa Zibelnik   +4 more
doaj   +1 more source