Results 141 to 150 of about 82,136 (245)

Enhanced global storm surges by tropical cyclone poleward migration. [PDF]

Proc Natl Acad Sci U S A
Guo YP, Tan ZM.
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Subsidence more than doubles sea-level rise today along densely populated coasts. [PDF]

Nat Commun
Oelsmann J, Nicholls RJ, Lincke D, Marcos M, Shirzaei M, Sánchez L, Ohenhen L, Dettmering D, Hinkel J, Horton BP, Seitz F.   +10 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Observations of the Rate and Acceleration of Global Mean Sea Level Change [PDF]

Bulletin of the American Meteorological Society, 2019
R. S. Nerem, J. Fasullo
openaire   +1 more source

Impacts of future sea level change on Greenland from community knowledge, coastal mapping, and glacial isostatic adjustment models. [PDF]

Proc Natl Acad Sci U S A
Tinto KJ, Austermann J, Bell RE, Blockley D, Brayton CE, Krawczyk D, Lewright L, Lloyd AJ, Nitsche FO, Paxman GJG, Porter DF, Sørensen A, Turrin M, Zinglersen K.   +13 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

A global chronologically standardised database of high-resolution proxy sea-level reconstructions since 1800 CE. [PDF]

Sci Data
Williams SL, Jackson LP, Garrett E, Hibbert FD, Gehrels WR.   +4 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Sea level much higher than assumed in most coastal hazard assessments. [PDF]

Nature
Seeger K, Minderhoud PSJ.
europepmc   +1 more source