Results 121 to 130 of about 800,769 (290)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

State of the climate 2014 [PDF]

Air and ocean temperatures across Australia are now, on average, almost a degree Celsius warmer than they were in 1910, with most of the warming occurring since 1950, according to this report.

core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Figure 1 — Indicative Change in Design ARI as Rainfall Intensities Increase [PDF]

Climate change is expected to have adverse impacts upon sea levels and rainfall intensities, both of which may have significant influence on flood behaviour at specific locations. IPCC 2007 trends indicate that average global sea level rise (ignoring ice
Ari Yrs
core  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Monthly mean forecast experiments with the GISS model [PDF]

The GISS general circulation model was used to compute global monthly mean forecasts for January 1973, 1974, and 1975 from initial conditions on the first day of each month and constant sea surface temperatures.
Atlas, R. M., Kuo, E., Spar, J.
core   +1 more source

Evaluating model simulations of 20th century sea-level rise. Part 1: Global mean sea-level change [PDF]

, 2017
Sea-level change is one of the major consequences of climate change and is projected to affect coastal communities around the world. Here, we compare Global Mean Sea-Level (GMSL) change estimated by 12 climate models from the 5th phase of the World Climate Research Programme’s Climate Model Intercomparison Project (CMIP5) to observational estimates for
Slangen, Aimée B. A., Meyssignac, Benoit, Agosta, Cecile, Champollion, Nicolas, Church, John A., Fettweis, Xavier, Ligtenberg, Stefan R. M., Marzeion, Ben, Melet, Angelique, Palmer, Matthew D., Richter, Kristin, Roberts, Christopher D., SPADA, GIORGIO   +12 more
openaire   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

The Influence on Climate Change of Differing Scenarios for Future Development Analyzed Using the MIT Integrated Global System Model [PDF]

, 2008
and PDF report are also available on the MIT Joint Program on the Science and Policy of Global Change website (http://globalchange.mit.edu/).A wide variety of scenarios for future development have played significant roles in climate policy discussions ...
Jacoby, Henry D., Paltsev, Sergey, Prinn, Ronald G., Reilly, John M., Sarofim, Marcus C., Sokolov, Andrei P.   +5 more
core   +1 more source