Results 111 to 120 of about 800,769 (290)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Earth Science, Systems and SocietyWe estimate ice-volume driven (barystatic; BSL) sea-level changes for the Cenozoic using new Mg/Ca data from 58 to 48 Ma and a revised analysis of Mg/Ca trends over the past 66 Myr.
K. G. Miller +6 more
doaj +1 more source
Simulations of the monthly mean atmosphere for February 1976 with the GISS model [PDF]
Monthly mean simulations of the global atmosphere were computed for February 1976 with the GISS model from observed initial conditions. In a replication experiment, two of these computations generated slightly different monthly mean states, apparently ...
Lutz, R. J., Spar, J.
core +1 more source
A global low order spectral model designed for climate sensitivity studies [PDF]
, 1984 A two level, global, spectral model using pressure as a vertical coordinate is developed. The system of equations describing the model is nonlinear and quasi-geostrophic.
Hanna, A. F., Stevens, D. E.
core +1 more source
A weekly Arctic sea-ice thickness data record from merged CryoSat-2 and SMOS satellite data [PDF]
, 2017 Sea-ice thickness on a global scale is derived from different satellite sensors using independent retrieval methods. Due to the sensor and orbit characteristics, such satellite retrievals differ in spatial and temporal resolution as well as in the ...
Haas, Christian +5 more
core +3 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Global climate evolution during the last deglaciation [PDF]
, 2012 Deciphering the evolution of global climate from the end of the Last Glacial Maximum approximately 19 ka to the early Holocene 11 ka presents an outstanding opportunity for understanding the transient response of Earth’s climate system to external and ...
Adkins, Jess F., Clark, Peter U.
core +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
GeoHazardsThe relatively new sea level satellite altimetry and secular coastal tide gauge data made the reconstruction of sea levels on regional and global scales possible about one century back. Due to better estimations of the Earth’s crustal, glacial, tectonic,
Krešo Pandžić +3 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source