Results 41 to 50 of about 539,883 (266)

Integrating mental health and development: a case study of the BasicNeeds Model in Nepal. [PDF]

, 2012
As one article in a series on Global Mental Health Practice, Shoba Raja and colleagues provide a case study of BasicNeeds in Nepal, which emphases user empowerment, community development, health systems strengthening, and policy change to help socially ...
Vikram Patel, Mannarath Saju, Sarah Kippen Wood, Shrestha Padam, Padam Shrestha, Saju Mannarath, Patel Vikram, Underhill, Chris, Chris Underhill, Raja, Shoba, Wood Sarah Kippen, Patel, Vikram, Raja Shoba, Wood, Sarah Kippen, Underhill Chris, Shrestha, Padam, Sunder Uma, Mannarath, Saju, Uma Sunder, Shoba Raja, Sunder, Uma   +20 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Community Mental Health Competencies: A New Vision for Global Mental Health

, 2017
As part of the Movement for Global Mental Health’s efforts to scale up services, attention has shifted to the level of communities, with community engagement recognised as a key locus of action to promote treatment and rehabilitation.
Kaaren Mathias, Rochelle Burgess, Mathias, Kaaren,, Burgess, Rochelle,   +3 more
core   +1 more source

Enhanced primary mental healthcare for Indigenous Australians: service implementation strategies and perspectives of providers

Global Health Research and Policy, 2018
Background Improving access to culturally appropriate mental healthcare has been recognised as a key strategy to address the often greater burden of mental health issues experienced by Indigenous populations.
Lennart Reifels, Angela Nicholas, Justine Fletcher, Bridget Bassilios, Kylie King, Shaun Ewen, Jane Pirkis   +6 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Mobile Mental Health [PDF]

, 2022
Several people with mental health problems do not receive suitable treatment and often avoid or delay seeking help due to concerns about being treated differently and other practical barriers (for example, services costs and unavailability).
Simões De Almeida, Raquel, Raquel Simões de Almeida   +1 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Philanthropy for global mental health 2000-2015 [PDF]

, 2020
Background Mental disorders are the leading cause of years lived with disability worldwide. While over three-quarters of people with mental disorders live in low- and middle-income countries (LMICs) and effective low-cost interventions are available ...
Iemmi, Valentina
core   +1 more source

How best to provide help to bereaved adolescents: a Delphi consensus study

BMC Psychiatry, 2021
Background Many adolescents struggle with their grief and mental health issues after the death of a close person, such as a family member or a friend. Given the potentially devastating impact of the loss on the adolescent and their family, professional ...
Anna M Ross, Karolina Krysinska, Debra Rickwood, Jane Pirkis, Karl Andriessen   +4 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source