Results 81 to 90 of about 542,547 (265)

Covid-19 and Global Networks: Reframing our understanding of globalization and transnationalism. [PDF]

Glob Netw (Oxf), 2023
Beaverstock JV, Cohen R, Rogers A, Vertovec S.   +3 more
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Radiation Risk in Cold War Mexico: Local and Global Networks. [PDF]

NTM, 2022
Barahona A.
europepmc   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Lead-DBS v3.0: Mapping deep brain stimulation effects to local anatomy and global networks. [PDF]

Neuroimage, 2023
Neudorfer C, Butenko K, Oxenford S, Rajamani N, Achtzehn J, Goede L, Hollunder B, Ríos AS, Hart L, Tasserie J, Fernando KB, Nguyen TAK, Al-Fatly B, Vissani M, Fox M, Richardson RM, van Rienen U, Kühn AA, Husch AD, Opri E, Dembek T, Li N, Horn A.   +22 more
europepmc   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Knowledge Sharing to Reduce Toxin Exposure Risks from Harmful Algal Blooms: Global Networks and Political Barriers. [PDF]

Ethn Dis, 2022
Roland HB, Whitehead C, Fleming LE, Berdalet E, Enevoldsen HO, Gribble MO.   +5 more
europepmc   +1 more source

The global innovation networks and global production networks of firms: Conceptualization and implication [PDF]

African Journal of Science, Technology, Innovation and Development, 2017
Today’s developments in the literature about the global networks of firms emphasize not only global production networks (GPNs) but also global innovation networks (GINs). However, the differences, commonalities and interaction between firms’ GINs and GPNs have not been theoretically and empirically clarified.
openaire   +3 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Global Hybrid Routing for Scale-Free Networks

IEEE Access, 2019
The performance of routing strategies on complex networks can be characterized by two measurements, i.e., the traffic capacity and the average packets travel time.
Xiong Gao, Hongxiang Guo, Yanhu Chen, Yinan Tang, Cen Wang, Shengyao Xu, Jian Wu   +6 more
doaj   +1 more source