Results 141 to 150 of about 1,590,381 (357)

Expression and purification of E140 protein antigen fragments of Plasmodium vivax and Plasmodium berghei for serological assays

open access: yesFEBS Open Bio, EarlyView.
We provide a step‐by‐step guide for producing E140 antigen fragments from Plasmodium berghei (Pb1) and Plasmodium vivax (Pv1). Pb1/Pv1 are expressed in E. coli, solubilized by freeze–thawing, refolded by slow dilution, purified by affinity chromatography (IMAC), then concentrated and subjected to quality control.
Rodolfo Ferreira Marques   +5 more
wiley   +1 more source

Interleaving Optimization with Sampling-Based Motion Planning (IOS-MP): Combining Local Optimization with Global Exploration [PDF]

open access: yesarXiv, 2016
Computing globally optimal motion plans for a robot is challenging in part because it requires analyzing a robot's configuration space simultaneously from both a macroscopic viewpoint (i.e., considering paths in multiple homotopic classes) and a microscopic viewpoint (i.e., locally optimizing path quality).
arxiv  

Identification of inhibitors of the Salmonella FraB deglycase, a drug target

open access: yesFEBS Open Bio, EarlyView.
A high‐throughput screen was used to identify inhibitors of Salmonella FraB, a drug target. Characterization of top hits (identified after an additional counter screen) revealed that some triazolidines, thiadiazolidines, and triazolothiadiazoles are mixed‐type inhibitors of FraB.
Jamison D. Law   +6 more
wiley   +1 more source

NON-LINEAR OPTIMIZATION METHODS FOR SMALL EARTHQUAKE LOCATIONS

open access: yesTASK Quarterly, 2004
The problem of locating mine tremors using P-wave arrival times is revisited in the paper. A multidimensional, global, non-linear, constrained optimization method is used as a minimization algorithm for tremor location.In order to see the general ...
GRZEGORZ PSZCZOŁA, ANDRZEJ LEŚNIAK
doaj  

Information-Aware Secure Routing in Wireless Sensor Networks

open access: yesSensors, 2019
Secure routing is crucial for wireless sensor networks (WSNs) because they are vulnerable to various attacks. In this paper, we propose a new secure routing protocol for WSNs in the presence of malicious nodes.
Qiong Shi   +5 more
doaj   +1 more source

A technique of global optimization of microprograms [PDF]

open access: bronze, 1978
Mario Tokoro   +3 more
openalex   +1 more source

Restricted global optimization for QAOA

open access: yesAPL Quantum
The Quantum Approximate Optimization Algorithm (QAOA) has emerged as a promising variational quantum algorithm for addressing NP-hard combinatorial optimization problems. However, a significant limitation lies in optimizing its classical parameters, which is in itself an NP-hard problem.
Peter Gleißner   +2 more
openaire   +3 more sources

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

open access: yesFEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi   +2 more
wiley   +1 more source

Material properties updating of honeycomb sandwich plates using a global optimization technique based on response surface model

open access: yesCailiao gongcheng, 2019
Honeycomb sandwich plates are used widely in the aerospace industry. Building accurate finite element models of honeycomb sandwich plates is necessary for analyzing and optimizing the microvibration that occurs in spacecraft.
SUN Wei-qing, CHENG Wei
doaj   +1 more source

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