Results 141 to 150 of about 140,448 (250)

Neighborhood Walkability Is Associated With Global Positioning System-Derived Community Mobility of Older Adults. [PDF]

J Gerontol A Biol Sci Med Sci
Moored KD, Crane BM, Carlson MC, Dunlap PM, Brach JS, Rosso AL.   +5 more
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Use of Accelerometry and Global Positioning System (GPS) to Describe Children's Park-Based Physical Activity Among Racial and Ethnic Minority Youth. [PDF]

J Urban Health
Alberico C, Zweig M, Carter A, Hughey SM, Huang JH, Schipperijn J, Floyd MF, Hipp JA.   +7 more
europepmc   +1 more source

Acute and Chronic Workload Ratios of Perceived Exertion, Global Positioning System, and Running-Based Variables Between Starters and Non-starters: A Male Professional Team Study. [PDF]

Front Psychol, 2022
Nobari H, Alijanpour N, Martins AD, Oliveira R.   +3 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Dynamic Bidirectional Associations Between Global Positioning System Mobility and Ecological Momentary Assessment of Mood Symptoms in Mood Disorders: Prospective Cohort Study. [PDF]

J Med Internet Res
Lee TY, Chen CH, Chen IM, Chen HC, Liu CM, Wu SI, Hsiao CK, Kuo PH.   +7 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Implementing global positioning system trackers for people with dementia who are at risk of wandering. [PDF]

Dementia (London)
Doyle M, Nwofe ES, Rooke C, Seelam K, Porter J, Bishop D.   +5 more
europepmc   +1 more source

Measuring Outdoor Walking Capacities Using Global Positioning System in People with Multiple Sclerosis: Clinical and Methodological Insights from an Exploratory Study. [PDF]

Sensors (Basel), 2021
Delahaye C, Chaves D, Congnard F, Noury-Desvaux B, de Müllenheim PY, On Behalf Of The Socos Group.   +5 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source