Results 71 to 80 of about 22,812,475 (283)

OTUD6A‐Mediated Deubiquitination of PRDX1 Protects Against Oral Ulcer by Restoring Mitochondrial Function

Advanced Science, EarlyView.
In human oral keratinocytes, OTUD6A promoted cell migration by deubiquitinating and stabilizing PRDX1. Conversely, OTUD6A deficiency reduced PRDX1 stability, triggering mitochondrial dysfunction and aggravating OU progression. ABSTRACT Oral ulcers (OU), as the most highly prevalent and recurrent oral mucosal lesion, have an unclear pathogenesis that ...
Xiaoyu Sun, Ruiwei Jia, Xingbei Pan, Rui Huang, Jiahong Chen, Ziyi Yao, Lei Yin, Jun Ma, Hongjieliang Wang, Xinyu Huang, Yilin Ma, Yifan Ping, Yuanyuan Chen, Huining Wang, Shengbin Huang, Guang Liang   +15 more
wiley   +1 more source

Similarity‐Enhanced Representation Learning of Non‐Canonical Amino Acids for Therapeutic Peptide Modeling

Advanced Science, EarlyView.
Non‐canonical amino acids (ncAAs) enhance peptide therapeutics but remain difficult to model computationally. SinCAA, a similarity‐enhanced pretraining framework, jointly optimizes contrastive learning guided by a novel conformational similarity metric with masked node reconstruction, capturing both functional relationships and chemical identity of ...
Chencheng Xu, Lesong Wei, Jianmin Wang, Yuanpeng Xiong, Ruochi Zhang, Yu Wang, Chao Zha, Qiangcheng Zeng, Xin Gao   +8 more
wiley   +1 more source

GPS-RTK Integrated with Micro-Electro Mechanical INS for Precise Application [PDF]

فصلنامه علوم و فناوری فضایی, 2012
Inertial Navigation System (INS) and Global Positioning System (GPS), are used in various navigation and positioning applications. Because each of the INS and GPS technologies has some limitations and advantages, during last two decades, the systems ...
Jamal Asgari, Ali Reza Amiri -Simkooei, Farzane Zanganeh-nejad   +2 more
doaj  

Multimodal Imaging of Hypoxia, Metabolism and pH in Feline Sarcoma Using Hyperpolarized 13C MRI and PET

Advanced Science, EarlyView.
This work presents a clinically deployable simultaneous PET/MRI workflow which integrates hyperpolarized 13C imaging of metabolism and extracellular pH with [18F]FMISO PET to characterize hypoxia, acidosis, and metabolic reprogramming in feline sarcoma.
Martin Grashei, Tanja Groll, Stephanie Kahl, Silke Baer, Elisabeth Bliemsrieder, Frits H. A. van Heijster, Andre Wendlinger, Pascal Wodtke, Jorge Cabello, Susan Notohamiprodjo, Christian Lohrmann, Markus Schwaiger, Wolfgang A. Weber, Katja Steiger, Andrea Meyer‐Lindenberg, Johannes Hirschberger, Christine Baumgartner, Franz Schilling   +17 more
wiley   +1 more source

BDS/GPS Multi-System Positioning based on Nonlinear Filter Algorithm [PDF]

, 2016
The Global Navigation Satellite System can provide all-day three-dimensional position and speed information. Currently, only using the single navigation system cannot satisfy the requirements of the system's reliability and integrity. In order to improve
Jae Hyok Kong, Xuchu Mao
core  

Deflection and frequency monitoring of the Forth Road Bridge, Scotland, by GPS [PDF]

, 2012
Permission is granted by ICE Publishing to print one copy for personal use. Any other use of these PDF files is subject to reprint fees. Copyright © 2012 Thomas Telford Ltd.The use of carrier phase kinematic GPS (global positioning system) has evolved ...
Brown, CJ, Roberts, GW, Brown, Christopher J., Atkins, Christopher, Meng, X, Roberts, Gethin W., Meng, Xiaolin, Atkins, C, Colford, Barry, Ogundipe, O, Ogundipe, Oluropo, Colford, B   +11 more
core   +1 more source

The Southeastern Sicily GPS network

Annals of Geophysics, 1995
The area located between Catania and Syracuse (Southeastern Sicily), characterised by the presence of the Simeto-Scordia-Lentini graben, was affected in the past by a strong seismicity as proved by the occurrence of seismic events strong enough to reach ...
F. Broccio, P. Baldi, M. Anzidei, V. Achilli, R. Velardita   +4 more
doaj   +1 more source

High‐Brightness and Ultra‐Long‐Lifetime Spin Quantum Dot Light‐Emitting Diodes Enabled by Efficient Injection of Spin‐Polarized Holes Through a Hybrid Hole Transport Layer

Advanced Science, EarlyView.
This work employs a hybrid hole transport layer to enhance hole transport efficiency, resulting in improved performance for the final device. It achieves an external quantum efficiency of 6.68%, a circularly polarized electroluminescence asymmetry factor of 0.026, and a high luminance of 14,370 cd/cm2, representing the highest luminance reported to ...
Fengqi Qiu, Hechun Zhang, Wenbo Liu, Guiming Zhong, Fumin Lu, Yuqi Wang, Fujin Ai, Kai Wang, Dan Wu   +8 more
wiley   +1 more source

SCTR–Expressing Astrocyte–Serotonergic Neuron Signaling Drives Sexual Dimorphism in Depression Through KAT7/H4ac–Foxc2 Epigenetic Axis in an AMPK‐Dependent Manner

Advanced Science, EarlyView.
Astrocytic SCTR modulates depressive‐related phenotypes via AMPKα1, whereas lowered Mt1 blunts Megalin‐dependent AMPKα2 signaling in serotonergic neurons. Diminished AMPKα2 hinders KAT7 nuclear translocation, curtails KAT7 occupancy and H4K8ac at the Foxc2 promoter, and represses Foxc2 transcription, revealing cell‐type‐specific AMPK‐linked epigenetic ...
Fantao Meng, Jing Liu, Juanjuan Dai, Min Wu, Wentao Wang, Mengdi Zhang, Shujun Jiang, Yifan Cao, Lihong Xu, Lin Du, Dan Wang, Di Zhao, Gaofeng Qin, Dong Wang, Wei Li, Chen Li   +15 more
wiley   +1 more source

Research on Beidou and GPS dual satellite positioning algorithms for substation site positioning

International Journal of Metrology and Quality Engineering, 2020
With the rapid development of global satellite navigation system technology, multi-mode satellite navigation positioning technology that can be compatible with multiple navigation systems at the same time is bound to become the future development trend ...
Feng Junjie, Shi Junfeng, Gao Lei, Huang Hongwei   +3 more
doaj   +1 more source