Results 101 to 110 of about 1,312,704 (343)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
, 2012 The last 30 years have seen a major trend towards the internationalisation of production. In some industry sectors this process has become global as production systems have been integrated on an inter-continental basis.
Smith, DJ, Williams, DA
core
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Global Production Networks and Industrial Upgrading in China: The Case in Electronics Contract Manufacturing. [PDF]
The paper analyzes the networks of U.S. and Taiwan based electronics contract manufacturers in South China, today the world´s most important location for low-cost mass production in the electronics industry.
Boy Luethje
core
Altered topology of the functional speech production network in non-fluent/agrammatic variant of PPA
Cortex; a journal devoted to the study of the nervous system and behavior, 2018 Non-fluent/agrammatic primary progressive aphasia (nfvPPA) is caused by neurodegeneration within the left fronto-insular speech and language production network (SPN). Graph theory is a branch of mathematics that studies network architecture (topology) by
M. Mandelli +21 more
semanticscholar +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
How Sustainable are Benefits from Global Production Networks? Malaysia's Upgrading Prospects in the Electronics Industry [PDF]
The paper introduces an operational definition of industrial upgrading (IU and documents the emergence of complex, multi-tier "networks of networks" which provide new opportunities for IU, but which also raise threshold requirements for participating in ...
Dieter Ernst
core
Global Spatially-Disaggregated Crop Production Statistics Data for 2020 Version 1.0
The 2020 SPAM (Spatial Production Allocation Model) products, encompassing crop area, yield, and production at a 5-minute grid resolution, have been developed by Zhe Guo, Shuang Zhou, and Liangzhi You. Employing a diverse range of inputs, IFPRI's Spatial
International Food Policy Research Institute (IFPRI)
core +1 more source