Results 111 to 120 of about 16,316,574 (299)

Towards the Internet as a Global Public Good

open access: yesThe Journal of Community Informatics, 2013
Editorial: Towards the Internet as a Global Public ...
openaire   +2 more sources

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

Public Goods and the Distribution of Income [PDF]

open access: yes
This article addresses conceptual issues concerning the distributive incidence of public goods. Solutions depend on the specific purposes for asking the question of distributive incidence notably, assessing the extent to which various public goods should
Louis Kaplow
core  

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

open access: yesMolecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba   +5 more
wiley   +1 more source

The Effects of Group Interaction in a Public Goods Experiment With Two Exchanges [PDF]

open access: yes
Consumers can often allocate resources to the provision of local public goods and to the provision of global public goods. This paper reports a public goods experiment in which participants allocated tokens to a local exchange with a relatively high ...
Yoav Wachsman
core  

FINANCING GLOBAL PUBLIC GOODS [PDF]

open access: yes, 2017
Küresel kamusal mallar kavramı, içinde bulunduğumuz yüzyılda küreselleşme olgusuyla birlikte anılmaktadır. Klasik kamu maliyesi yazınında tüketimde rekabetin olmaması ve dışlanamama temel karakteristikleri kamusal malları tanımlamakta kullanılırken hızla
Dedebek, Emin
core   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

open access: yesMolecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara   +10 more
wiley   +1 more source

What role for public goods in the future of CAP? [PDF]

open access: yes
The European Union’s Common Agricultural Policy continues to evolve. The public debate about its future post 2013 was launched in April 2010 and a formal Commission Communication on the future of the Common Agriculture Policy (CAP) was published in ...
Harvey, David R., Jambor, Attila
core  

Small RNA pathways in mammalian oocytes

open access: yesFEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Dynamics of Provision of Threshold Public Goods [PDF]

open access: yes
Agents face an ambiguous risk of biodiversity survival as well as ambiguous expected losses from its extinction. As a collectivity, agents are faced with the option of privately funding the protection of biodiversity for biomedical research.
Arnaud Dragicevic, Jim Engle-Warnick
core  

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