Results 91 to 100 of about 16,316,574 (299)
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Patenting the Sun? Possible Exclusion of SRM Technologies from Patenting and Risk Regulation
European Journal of Risk RegulationIn an interview with Jonas Salk, the inventor of the first polio vaccine, when asked whether he owned the patents for the vaccine, Salk replied with a rhetorical question: “Could you patent the sun?” Decades later, patents about the Sun indeed emerged as
Wenting Cheng
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
INTERNATIONAL FINANCIAL INSTITUTIONS AND INTERNATIONAL PUBLIC GOODS: OPERATIONAL IMPLICATIONS FOR THE WORLD BANK [PDF]
The global International Financial Institutions (IFIs) increasingly justify their operations in terms of the provision of International Public Goods (IPGs).
Ravi KANBUR
core
Globalization and Biodiversity Conservation Problems: Polycentric REDD+ Solutions
Land, 2019 Protected areas are considered the cornerstone of biodiversity conservation, but face multiple problems in delivering this core objective. The growing trend of framing biodiversity and protected area values in terms of ecosystem services and human well ...
Mwangi Githiru, Josephine W. Njambuya
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Energy Market Integration in East Asia: A Regional Public Goods Approach [PDF]
This study applies a regional public goods approach to the study of energy market integration (EMI) in East Asia, with a view to clarifying the outlook for such integration and the likely obstacles to be encountered. In addition to drawing on theoretical
Philip ANDREWS-SPEED
core
Informative Voting and the Samuelson Rule [PDF]
, 2006 We study the classical free-rider problem in public goods provision in a large economy with uncertainty about the average valuation of the public good. Individual preferences over public goods are shaped by a skill and a taste parameter.
Sahm, M. +3 more
core +1 more source
The public goods hypothesis for the evolution of life on Earth
Biology Direct, 2011 It is becoming increasingly difficult to reconcile the observed extent of horizontal gene transfers with the central metaphor of a great tree uniting all evolving entities on the planet. In this manuscript we describe the Public Goods Hypothesis and show
Bapteste Eric +3 more
doaj +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source