Results 71 to 80 of about 57,885 (299)
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Customary international law and public goods [PDF]
, 2015 The paper examines the potential of customary international law to protect global public goods. In particular, it focuses on the question whether customary law can contribute to the mitigation of climate change.
Petersen, N., Petersen, Niels
core
Global public goods and health: taking the agenda forward
Bulletin of the World Health Organization, 2001 We examined recent special health initiatives to control HIV/AIDS, malaria, and tuberculosis, and make four policy recommendations for improving the sustainability of such initiatives. First, international cooperation on health should be seen as an issue
Kaul Inge, Faust Michael
doaj
Legitimizing Private Actors in Global Governance: From Performance to Performativity
Politics and Governance, 2017 Global governance is frequently criticised because of major legitimacy deficits, including lack of public accountability and democratic control. Within this context, questions about the legitimacy of non-state governance actors, such as non-governmental ...
Elke Krahmann
doaj +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Financing the Provision of Global Public Goods [PDF]
The World Economy, 2004 This paper examines the concept of global public goods (GPGs) and in that context explores the extent of aid (ODA) presently being diverted to GPG provision and whether such diversion skews aid‐flows towards some recipients. These are examined on the basis of OECD data for the late 1990s.
openaire +3 more sources
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Financing the Provision of Global Public Goods [PDF]
global public goods, international organizations, aid, externality, Global Environment ...
Anand, P.B.
core
Indirect tax harmonization and global public goods [PDF]
, 2014 Journal Article“The final publication is available at Springer via http://dx.doi.org/10.1007/s10797-012-9246-8”.This paper identifies conditions under which, starting from any tax-distorting equilibrium, destination- and origin-based indirect tax ...
Karakosta, Ourania +3 more
core +1 more source