Results 61 to 70 of about 57,885 (299)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Global Public Economics: Public Goods and Externalities [PDF]
Économie publique/Public economics, 2007 Cet article étend l’analyse normative des biens publics et des externalités à un environnement international. La première partie considère l’allocation optimale d’un bien public global. Le caractère désirable de l’efficacité productive globale dépend de l’existence de transferts forfaitaires internationaux.
openaire +2 more sources
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Impure Public Goods and Technological Interdependencies [PDF]
Impure public goods represent an important group of goods. Almost every public good exerts not only effects which are public to all but also effects which are private to the producer of this good.
Rübbelke, Dirk T. G., Löschel, Andreas
core +2 more sources
Financing Global Common Goods for Health: When the World is a Country
Health Systems & Reform, 2019 “Global functions” of health cooperation refer to those activities that go beyond the boundaries of individual nations to address transnational issues.
Gavin Yamey +3 more
doaj +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
As ruralidades nas políticas globais
Desenvolvimento e Meio Ambiente, 2015 This paper aims at providing a scheme, theoretical and historical as well, of contemporaneous changes of rural societies by referring to the specific experience of west-European countries. This concept of rural – that opened the field of rural sociology –
Marc Mormont
doaj +1 more source
The Belt and Road Initiative and the AIIB: Potential Impact on the Economic Architecture of Asia
Вестник Московского Университета. Серия XXV: Международные отношения и мировая политика, 2020 Dynamics of economic development in Asia in the first two decades of the 21st century can be visualized schematically as a series of waves with different focuses of economic activities of regional powers and prevailing regional economic agenda. The first
Ya. V. Leksyutina
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source