Results 81 to 90 of about 57,885 (299)

The Welfare Economics of Global Public Goods [PDF]

open access: yesSSRN Electronic Journal, 2007
This paper studies the conditions for a welfare-maximizing allocation of resources to the production of global public goods, such as biodiversity, the global climate, the cultural heritage, knowledge, and world peace. A global social welfare function is maximized subject to production constraints and alternative assumptions about the possibility of ...
openaire   +2 more sources

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

open access: yesMolecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou   +12 more
wiley   +1 more source

Propriété, biens publics mondiaux, bien(s) commun(s) : Une lecture des concepts économiques

open access: yesDéveloppement Durable et Territoires, 2008
Property, Global Public Goods, Common Good(s) : A Lecture. The concept of global public good emerged these last years. It proposes, in an ambiguous way, to go beyond the usual concept of public good.
Jérôme Ballet
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

On financing global and international public goods [PDF]

open access: yes
Three dimensions of public goods--nonrivalry of benefits, the possibility of being excluded from benefits, and the technology for aggregating public supply--determine what kinds of institutions and transnational actions are required for their provision ...
Sandler, Todd
core  

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

Global and regional public goods: a prognosis for collective action [PDF]

open access: yes
This paper applies modern concepts from the theory of public goods to indicate why progress has been made with respect to some global and regional public goods (for example, cutting sulphur emissions) but not with respect to others (for example, cutting ...
Todd Sandler
core  

Island Climate Change Adaptation and Global Public Goods Within the Belt and Road Initiative

open access: yesIsland Studies Journal, 2020
The Belt and Road Initiative (BRI), a project conceptualized and developed by the Chinese state, aims to enhance international cooperation, address issues of shared regional and global concern, and create opportunities for foreign direct investment in ...
Chunlin Li   +2 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Global Public Goods: the Participatory Governance Challenges

open access: yes, 2012
Global public goods (GPGs)--the economic term for a broad range of goods and services that benefit everyone, including stable climate, public health, and economic security--pose notable governance challenges. At the national level, public goods are often
Dedeurwaerdere, Tom, Brousseau, Eric
core  

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