Science as a global public good: responding to challenges of the modern eraScience as a global public good: responding to challenges of the modern era [PDF]
Royal Society Open ScienceScience has been crucial to the creation of the modern world and is essential in navigating its complexities. Well-informed citizens, willing to change perspectives in the face of new evidence, are essential to democracy.
Geoffrey S. Boulton
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A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
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Global Public Goods: the Participatory Governance Challenges
, 2012 Global public goods (GPGs)--the economic term for a broad range of goods and services that benefit everyone, including stable climate, public health, and economic security--pose notable governance challenges. At the national level, public goods are often
Dedeurwaerdere, Tom, Brousseau, Eric
core
Can science diplomacy help safeguard science as a global public good? Reflections on strategy, data and peopleCan science diplomacy help safeguard science as a global public good? Reflections on strategy, data and people [PDF]
Royal Society Open ScienceIn a world where geopolitical tensions strongly impinge on international scientific collaboration and where some scientific information has significant commercial value, the notion of science and practice of it as a global public good are under pressure ...
Angela Liberatore
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
A Planner of Global Income Transfers: International Public Goods and Productivity Differentials [PDF]
The purpose of this paper, by introducing the adjustment expense of global income transfers across N countries, is to produce an explicit rule for the planner country regarding income transfers, and to investigate the effects of income transfers on each ...
Tatsuyoshi Miyakoshi
core
Island Climate Change Adaptation and Global Public Goods Within the Belt and Road Initiative
Island Studies Journal, 2020 The Belt and Road Initiative (BRI), a project conceptualized and developed by the Chinese state, aims to enhance international cooperation, address issues of shared regional and global concern, and create opportunities for foreign direct investment in ...
Chunlin Li +2 more
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Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Propriété, biens publics mondiaux, bien(s) commun(s) : Une lecture des concepts économiques
Développement Durable et Territoires, 2008 Property, Global Public Goods, Common Good(s) : A Lecture. The concept of global public good emerged these last years. It proposes, in an ambiguous way, to go beyond the usual concept of public good.
Jérôme Ballet
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