Results 101 to 110 of about 1,133,811 (261)

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Global prevalence of multimorbidity during pregnancy: a systematic review and meta-analysis

Reproductive Health
Background Multimorbidity, defined as having two or more coexisting physical or mental health conditions, increases the risk of complications and need of specialist care during pregnancy.
Lena Elise Wessing, Shrouq Daraiseh, Yasmin Semmane, Adamantia Styliani Chassioti, Adhithi Sreenivasan, Veronika Tirado, Emily White Johansson, Renee Gardner, Sibylle Herzig van Wees, Claudia Hanson, Sunjuri Sun   +10 more
doaj   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

“Either you feel bad and stay, or you’re smart and leave” - perspectives from emergency department staff in Stockholm, Sweden

BMC Health Services Research
Background Job attrition and burnout among healthcare staff is a substantial challenge for healthcare systems globally. Staff working in emergency departments (ED) face work environment challenges including moral distress.
Clara Brune, Pernilla Lundmark, Lotta Nylén, Martina Gustavsson, Bo Burström, Johan von Schreeb, Ann Liljas   +6 more
doaj   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Risk factors for infection in older adults with home care: a mixed methods systematic review with meta-analysis

BMC Public Health
Worldwide, home care in the form of home healthcare and home help, has become increasingly more available. This systematic review aims to provide a deeper understanding of factors that are of particular importance for infection control in the home care ...
Ann Liljas, Madelene Barboza, Carmela Basanisi, Gabrielle Muzzi, Abaynesh Haftu Nigussie, Janne Agerholm, Bo Burström, Ester Gubi   +7 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Political economy of adolescent mental health and well-being in Sweden: how to overcome barriers to effective financing and youth-centered collective action

BMC Public Health
Background In Sweden, adolescents (10-19-year-olds) increasingly face problems related to their mental health and well-being, driving the rise in rates of mental ill-health (e.g., anxiety, depression, suicidal ideation and self-harm), and care-seeking ...
Olivia Biermann, Mariam Claeson, Mirjam Derko, Carolina Mikaelsdotter, Alma Nordenstam, Stefan Swartling Peterson   +5 more
doaj   +1 more source