Results 151 to 160 of about 2,615,111 (244)

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

An efficient and flexible framework for inferring global sensitivity of agent-based model parameters. [PDF]

PLoS Comput Biol
Bergman DR, Jackson T, Jain HV, Norton KA.   +3 more
europepmc   +1 more source

Global Sensitivity Analysis with Mixtures: A Generalized Functional ANOVA Approach. [PDF]

Risk Anal, 2022
Borgonovo E, Li G, Barr J, Plischke E, Rabitz H.   +4 more
europepmc   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Global Sensitivity Analyses of the APSIM-Wheat Model at Different Soil Moisture Levels. [PDF]

Plants (Basel)
Zhang Y, Ai P, Ma Y, Fu Q, Ma X.
europepmc   +1 more source

Global Sensitivity Analysis For Clinically Validated 1D Models of Fractional Flow Reserve. [PDF]

Annu Int Conf IEEE Eng Med Biol Soc, 2021
Tanade C, Feiger B, Vardhan M, Chen SJ, Leopold JA, Randles A.   +5 more
europepmc   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Accurate modeling of microwave structures in constrained domains using global sensitivity analysis and performance-based pre-screening. [PDF]

Sci Rep
Koziel S, Pietrenko-Dabrowska A.
europepmc   +1 more source

Global Sensitivity Analysis via a Statistical Tolerance Approach. [PDF]

Eur J Oper Res, 2022
Curry S, Lee I, Ma S, Serban N.
europepmc   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source