Results 141 to 150 of about 7,934,994 (308)

The National Global Change Research Plan 2012-2021: A Triennial Update

, 2017
This report is the third triennial update of the National Global Change Research Plan based on scientific research from 13 Federal agencies. The purpose of each update is to "advance science, inform decisions, conduct...assessments" and communicate ...
U.S. Global Change Research Program
core  

Analysing DSGE Models with Global Sensitivity Analysis

, 2008
Stability mapping, Reduced form solution, DSGE models, Monte Carlo filtering, Global sensitivity analysis, High dimensional model representation, C02, C60, C62, C63,
Marco Ratto, RATTO Marco
core   +1 more source

Proportional Marginal Effects for Global Sensitivity Analysis

SIAM/ASA Journal on Uncertainty Quantification
Performing (variance-based) global sensitivity analysis (GSA) with dependent inputs has recently benefited from cooperative game theory concepts.By using this theory, despite the potential correlation between the inputs, meaningful sensitivity indices can be defined via allocation shares of the model output's variance to each input.
Herin, Margot, Il Idrissi, Marouane, Chabridon, Vincent, Iooss, Bertrand   +3 more
openaire   +4 more sources

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Stability Evaluation of Slope Based on Global Sensitivity Analysis

Complexity
The uncertainty of parameters will have a significant impact on slope stability, where sensitivity analysis is a commonly used method in uncertainty research. However, traditional sensitivity analysis method costs much computation time.
Zhaoxia Xu, Xiuzhen Wang, Lu Guo, Teng Yu   +3 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Sensitivity of Pareto Solutions in Multiobjective Optimization. [PDF]

The paper presents a sensitivity analysis of Pareto solutions on the basis of the Karush-Kuhn-Tucker (KKT) necessary conditions applied to nonlinear multiobjective programs (MOP) continuously depending on a parameter.
Balbás, Alejandro, Jiménez Guerra, Pedro, Galperin, Effim   +2 more
core  

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

A new paradigm for global sensitivity analysis

CoRR
It is well-known that Sobol indices, which count among the most popular sensitivity indices, are based on the Sobol decomposition. Here we challenge this construction by redefining Sobol indices without the Sobol decomposition. In fact, we show that Sobol indices are a particular instance of a more general concept which we call sensitivity measures.
openaire   +3 more sources

Ambient air pollution undermines chemosensory sensitivity – a global perspective

Scientific Reports
This study offers insights into the complex relationship between chemical species constituting air pollution and chemosensory function. We examined the relationship between chemical species known to contribute to air pollution and assault human health ...
Anna Oleszkiewicz, Andrea Pozzer, Jonathan Williams, Thomas Hummel   +3 more
doaj   +1 more source