Results 231 to 240 of about 7,934,994 (308)

GLOBAL NONCOMMUNICABLE DISEASE : ADVANCING INNOVATIVE, EVIDENCE-BASED INTERVENTIONS TO PREVENT AND CONTROL NCDS

Noncommunicable diseases (NCDs), such as heart disease, stroke, cancer, chronic respiratory disease, and diabetes, are the leading cause of death and disability worldwide.To address this emerging global health challenge, the Division of Global Health ...

core  

Global sensitivity of EEG source analysis to tissue conductivity uncertainties. [PDF]

Front Hum Neurosci
Vorwerk J, Wolters CH, Baumgarten D.
europepmc   +1 more source

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source

Convergence, sampling and total order estimator effects on parameter orthogonality in global sensitivity analysis. [PDF]

PLoS Comput Biol
Saxton H, Xu X, Schenkel T, Clayton RH, Halliday I.   +4 more
europepmc   +1 more source

Using fluorescence fluctuation spectroscopy to quantify molecular dynamics within cells

FEBS Open Bio, EarlyView.
Microscopy techniques like fluorescence correlation spectroscopy (FCS) and number and brightness analysis (N&B) allow to quantify concentrations, diffusion rates, and oligomerization of fluorescently labeled molecules in the living cell. In this protocol the principles of how to set up these types of experiments are described including calibration ...
Mark A. Hink
wiley   +1 more source

Improved efficacy behavioral modeling of microwave circuits through dimensionality reduction and fast global sensitivity analysis. [PDF]

Sci Rep
Koziel S, Pietrenko-Dabrowska A, Leifsson L.   +2 more
europepmc   +1 more source

Ultrafast visual detection of Streptococcus suis via HtpsC‐targeted LAMP–CRISPR–Cas12a coupled with lateral flow immunochromatography

FEBS Open Bio, EarlyView.
A rapid visual test combines DNA amplification, CRISPR–based target verification, and a lateral flow strip to detect Streptococcus suis. The assay gives results in about 45 min, reduces false‐positive interpretation, and does not require fluorescence equipment.
Liu‐xin Li, Miao Xin, Xiao‐wen Cui, Shi‐yin Yu, Fei Meng, Min Cao, Xiao‐hui Xiong, Yi‐chen Lu   +7 more
wiley   +1 more source

Untangling the Molecular Interactions Underlying Intracellular Phase Separation Using Combined Global Sensitivity Analyses. [PDF]

Bull Math Biol
Gasior KI, Cogan NG.
europepmc   +1 more source

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source