Results 181 to 190 of about 913,957 (308)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Bayesian-calibrated global sensitivity analysis for mathematical models using generative AI. [PDF]

PLoS Comput Biol
Wang X.
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Global Sensitivity Analysis For Clinically Validated 1D Models of Fractional Flow Reserve. [PDF]

Annu Int Conf IEEE Eng Med Biol Soc, 2021
Tanade C, Feiger B, Vardhan M, Chen SJ, Leopold JA, Randles A.   +5 more
europepmc   +1 more source

Categorical Inputs, Sensitivity Analysis, Optimization and Importance Tempering with tgp Version 2, an R Package for Treed Gaussian Process Models

This document describes the new features in version 2.x of the tgp package for R, implementing treed Gaussian process (GP) models. The topics covered include methods for dealing with categorical inputs and excluding inputs from the tree or GP part of the
Robert B. Gramacy, Matthew Alan Taddy
core  

Recommended Practices in Global Sensitivity Analysis

, 2009
Practices for global sensitivity analysis of model output are described in a recent textbook (Saltelli et al., 2007). These include (i) variance based techniques for general use in modelling, (ii) the elementary effect method for factor screening for ...
SALTELLI Andrea, VIDONI Daniele, MASCHERINI Massimiliano   +2 more
core  

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

A comparative case study on the performance of global sensitivity analysis methods on digit classification. [PDF]

Discov Data
Sadeghi Z, Matwin S.
europepmc   +1 more source

Global Sensitivity Analysis via a Statistical Tolerance Approach. [PDF]

Eur J Oper Res, 2022
Curry S, Lee I, Ma S, Serban N.
europepmc   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source