Results 161 to 170 of about 2,456,167 (285)

Global Sensitivity Analysis in Life-Cycle Assessment of Early-Stage Technology using Detailed Process Simulation: Application to Dialkylimidazolium Ionic Liquid Production. [PDF]

ACS Sustain Chem Eng, 2023
Baaqel HA, Bernardi A, Hallett JP, Guillén-Gosálbez G, Chachuat B.   +4 more
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Global Sensitivity Analysis. The Primer [PDF]

, 2007
Andrea Saltelli, Marco Ratto, Terry Andres, Francesca Campolongo, Jessica Cariboni, Debora Gatelli, Michaela Saisana, Stefano Tarantola   +7 more
openaire   +1 more source

Bayesian-calibrated global sensitivity analysis for mathematical models using generative AI. [PDF]

PLoS Comput Biol
Wang X.
europepmc   +1 more source

Global Sensitivity Analysis with Mixtures: A Generalized Functional ANOVA Approach. [PDF]

Risk Anal, 2022
Borgonovo E, Li G, Barr J, Plischke E, Rabitz H.   +4 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Global Sensitivity Analysis For Clinically Validated 1D Models of Fractional Flow Reserve. [PDF]

Annu Int Conf IEEE Eng Med Biol Soc, 2021
Tanade C, Feiger B, Vardhan M, Chen SJ, Leopold JA, Randles A.   +5 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

A comparative case study on the performance of global sensitivity analysis methods on digit classification. [PDF]

Discov Data
Sadeghi Z, Matwin S.
europepmc   +1 more source

Global Sensitivity Analysis via a Statistical Tolerance Approach. [PDF]

Eur J Oper Res, 2022
Curry S, Lee I, Ma S, Serban N.
europepmc   +1 more source