Results 151 to 160 of about 913,957 (308)

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

open access: yesFEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda   +12 more
wiley   +1 more source

Local Sensitivity and Diagnostic Tests

open access: yes
In this paper we confront sensitivity analysis with diagnostic testing.Every model is misspecified, but a model is useful if the parameters of interest (the focus) are not sensitive to small perturbations in the underlying assumptions. The study of the e
Magnus, J.R., Vasnev, A.L.
core  

Global Sensitivity Analysis of Background Life Cycle Inventories. [PDF]

open access: yesEnviron Sci Technol, 2022
Kim A, Mutel CL, Froemelt A, Hellweg S.
europepmc   +1 more source

Temperature sensitivity of soil carbon decomposition [PDF]

open access: yes, 2013
The world's soils contain three times as much carbon as the atmosphere. Thus, any changes in this carbon pool may affect atmospheric CO₂ levels with implications for climate change.
Erhagen, Björn
core  

Analytical global sensitivity analysis with Gaussian processes

open access: yes, 2017
Methods for efficient variance-based global sensitivity analysis of complex high-dimensional problems are presented and compared. Variance decomposition methods rank inputs according to Sobol indices that can be computationally expensive to evaluate ...
Ankur Srivastava   +2 more
core   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

An Improved Copula‐Based Framework for Efficient Global Sensitivity Analysis

open access: yesWater Resources Research
Global sensitivity analysis (GSA) enhances our understanding of computational models and simplifies model parameter estimation. VarIance‐based Sensitivity analysis using COpUlaS (VISCOUS) is a variance‐based GSA framework.
Hongli Liu   +7 more
doaj   +1 more source

Analysis of Hepatic Lipid Metabolism Model: Simulation and Non-Stationary Global Sensitivity Analysis. [PDF]

open access: yesNutrients, 2022
Kosić M   +5 more
europepmc   +1 more source

Motion processing deficits in migraine are related to contrast sensitivity

open access: yes, 2012
Background: There are conflicting reports concerning the ability of people with migraine to detect and discriminate visual motion. Previous studies used different displays and none adequately assessed other parameters that could affect performance, such ...
Hine, Trevor   +8 more
core   +1 more source

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