Results 131 to 140 of about 913,957 (308)

Global stability analysis of 2D and fully 3D incompressible flows with applications to flow control

, 2013
Numerical tools for global linear stability and sensitivity analyses in fluid dynamics are developed in the present work. These tools are applied to the investigation and control of two- and three-dimensional internal flow configurations.
FANI, ANDREA
core  

Variogram method for Global Sensitivity Analysis

, 2019
We extend the “variogram-based” theory of Global Sensitivity Analysis, called Variogram Analysis of Response Surfaces (VARS), and develop a new generalized star sampling technique (called gSTAR) to accommodate correlated multivariate distributions.
Nhu Do (4191721)
core   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Fréchet-Derivative-Based Global Sensitivity Analysis and Its Physical Meanings in Structural Design

Applied Sciences
Sensitivity analysis is essential for uncertainty-based structural design and analysis, especially global sensitivity analysis, which can reflect the overall physical properties of large and complex computational models with stochastic parameters.
Weifeng Tao, Zhiqiang Wan, Xiuli Wang
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Multi-Stage Sensitivity Analysis of the Energy Demand for the Cooling of Grain Warehouses in Cold Regions of China

Agriculture
The early design parameters exert a considerable influence on the cooling energy demand of a granary building in operation. In order to investigate the impact of various parameters on energy use, a grain warehouse energy model was constructed using the ...
Hua Zhang, Junya Ye, Kunming Li, Shujie Niu, Xiao Liu   +4 more
doaj   +1 more source

Sensitivity analysis and related analysis: A survey of statistical techniques

This paper reviews the state of the art in five related types of analysis, namely (i) sensitivity or what-if analysis, (ii) uncertainty or risk analysis, (iii) screening, (iv) validation, and (v) optimization. The main question is: when should which type
Kleijnen, J.P.C.
core  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Predictor Importance for Hydrological Fluxes of Global Hydrological and Land Surface Models

Water Resources Research
Global Hydrological and Land Surface Models (GHM/LSMs) embody numerous interacting predictors and equations, complicating the understanding of primary hydrological relationships.
João Paulo L. F. Brêda, Lieke A. Melsen, Ioannis Athanasiadis, Albert VanDijk, Vinícius A. Siqueira, Anne Verhoef, Yijian Zeng, Martine van derPloeg   +7 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source