Results 111 to 120 of about 2,456,167 (285)
Global Sensitivity Analysis of Structural Reliability Using Cliff Delta
MathematicsThis paper introduces innovative sensitivity indices based on Cliff’s Delta for the global sensitivity analysis of structural reliability. These indices build on the Sobol’ method, using binary outcomes (success or failure), but avoid the need to ...
Zdeněk Kala
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Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
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Global perspectives on nitrate aerosol dynamics: a comprehensive sensitivity analysis [PDF]
Atmospheric Chemistry and PhysicsIn recent years, nitrate aerosols have become a dominant component of atmospheric composition, surpassing sulfate in both concentration and climatic impact. However, accurately simulating nitrate remains a major challenge for global models due to complex
A. Milousis +5 more
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RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
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Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Fréchet-Derivative-Based Global Sensitivity Analysis and Its Physical Meanings in Structural Design
Applied SciencesSensitivity analysis is essential for uncertainty-based structural design and analysis, especially global sensitivity analysis, which can reflect the overall physical properties of large and complex computational models with stochastic parameters.
Weifeng Tao, Zhiqiang Wan, Xiuli Wang
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Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
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AgricultureThe early design parameters exert a considerable influence on the cooling energy demand of a granary building in operation. In order to investigate the impact of various parameters on energy use, a grain warehouse energy model was constructed using the ...
Hua Zhang +4 more
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Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
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