Results 121 to 130 of about 2,456,167 (285)

Predictor Importance for Hydrological Fluxes of Global Hydrological and Land Surface Models

Water Resources Research
Global Hydrological and Land Surface Models (GHM/LSMs) embody numerous interacting predictors and equations, complicating the understanding of primary hydrological relationships.
João Paulo L. F. Brêda, Lieke A. Melsen, Ioannis Athanasiadis, Albert VanDijk, Vinícius A. Siqueira, Anne Verhoef, Yijian Zeng, Martine van derPloeg   +7 more
doaj   +1 more source

Uncertainty and sensitivity analysis of functional risk curves based on Gaussian processes

, 2016
A functional risk curve gives the probability of an undesirable event as a function of the value of a critical parameter of a considered physical system. In several applicative situations, this curve is built using phenomenological numerical models which
Gratiet, Loïc Le, Iooss, Bertrand
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Estimating the relative importance of epidemiological and behavioural parameters for epidemic mpox transmission: a modelling study

BMC Medicine
Background Many European countries experienced outbreaks of mpox in 2022, and there was an mpox outbreak in 2023 in the Democratic Republic of Congo. There were many apparent differences between these outbreaks and previous outbreaks of mpox; the recent ...
Madhav Chaturvedi, Isti Rodiah, Mirjam Kretzschmar, Stefan Scholz, Berit Lange, André Karch, Veronika K. Jaeger   +6 more
doaj   +1 more source

Local and global sensitivity analysis for railway upgrading between hydrogen fuel cell and electrification

High-Speed Railway
In the field of rail transit, the UK Department of Transport stated that it will realize a comprehensive transformation of UK railways by 2050, abandoning traditional diesel trains and upgrading them to new environmentally friendly trains.
Yizhe Zhang, Zhongbei Tian, Kangrui Jiang, Stuart Hillmansen, Clive Roberts   +4 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Generalized global sensitivity and correlation analysis

Information and Control, 1980
Quantities measuring sensitivities and correlations of parameters involved in an engineering system are systematically defined by means of lattice theory. Consideration of lattice duality leads to recognition of polymatroid structure of the sensitivity and correlation measures.
openaire   +2 more sources

Analysis of airfoil leading edge separation bubbles [PDF]

A local inviscid-viscous interaction technique was developed for the analysis of low speed airfoil leading edge transitional separation bubbles. In this analysis an inverse boundary layer finite difference analysis is solved iteratively with a Cauchy ...
Carter, J. E., Vatsa, V. N.
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source