Results 101 to 110 of about 2,456,167 (285)

National economic policy simulations with global interdependencies : a sensitivity analysis for Germany [PDF]

"Policy simulations for national economies with econometric models in general are done using a stand alone national model with exogenous export values and import prices. In a globalised world such an exercise is critical, since the policy in question may
Lutz, Christian, Meyer, Bernd, Schnur, Peter, Zika, Gerd   +3 more
core  

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Stability Evaluation of Slope Based on Global Sensitivity Analysis

Complexity
The uncertainty of parameters will have a significant impact on slope stability, where sensitivity analysis is a commonly used method in uncertainty research. However, traditional sensitivity analysis method costs much computation time.
Zhaoxia Xu, Xiuzhen Wang, Lu Guo, Teng Yu   +3 more
doaj   +1 more source

Wastewater Stabilisation Ponds System: Global Sensitivity Analysis on Network Design

Chemical Engineering Transactions, 2016
In this work, a wastewater treatment network (WWTN) consisting of a system of ponds is modelled rigorously, taking into account dynamic mass balances for the main groups of bacteria, together with different types of organic load, algae biomass, nutrients,
M.P. Ochoa, V. Estrada, P. Hoch
doaj   +1 more source

Overview of global scale research Doppler lidar activities [PDF]

Efforts in support of a global backscatter mission are reviewed briefly. Lidar system sensitivity was calibrated by means of ground-based tests. The analysis of ground-based data and planning of a global backscatter mission were conducted.
Fitzjarrald, D. E.
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Global sensitivity analysis in stability problems of steel frame structures

Journal of Civil Engineering and Management, 2016
Slender steel frame structures are characterised by a number of imperfections which may reduce their load carrying capacity drastically. This article studies the effects of these imperfections on the load carrying capacity of a single storey steel plane ...
Zdeněk Kala
doaj   +1 more source

Global water cycle [PDF]

The primary objective is to determine the scope and interactions of the global water cycle with all components of the Earth system and to understand how it stimulates and regulates changes on both global and regional scales.
Christy, John R., Fitzjarrald, Dan, Goodman, Steven J., Lapenta, Bill, Miller, Tim L., Robertson, Franklin R., Wang, Shouping   +6 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source