Results 101 to 110 of about 913,957 (308)

Global sensitivity analysis code and input data for PESHMELBA

, 2022
Global sensitivity analysis code and input data (sample and SA indices) for PESHMELBA for the paper "How to perform global sensitivity analysis of a catchment-scale, distributed pesticide transfer model ?
LAUVERNET, CLAIRE, ROUZIES, EMILIE
core   +1 more source

Proportional Marginal Effects for Global Sensitivity Analysis

SIAM/ASA Journal on Uncertainty Quantification
Performing (variance-based) global sensitivity analysis (GSA) with dependent inputs has recently benefited from cooperative game theory concepts.By using this theory, despite the potential correlation between the inputs, meaningful sensitivity indices can be defined via allocation shares of the model output's variance to each input.
Herin, Margot, Il Idrissi, Marouane, Chabridon, Vincent, Iooss, Bertrand   +3 more
openaire   +4 more sources

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Estimating sensitivity indices based on Gaussian process metamodels with compactly supported correlation functions

Specific formulae are derived for quadrature-based estimators of global sensitivity indices when the unknown function can be modeled by a regression plus stationary Gaussian process using the Gaussian, Bohman, or cubic correlation functions.
Svenson, Joshua, Dean, Angela M., Santner, Thomas, Moon, Hyejung   +3 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Theory to practice: global sensitivity analysis of the Aimsun meso model

, 2014
This paper examines a metamodel-based technique for model sensitivity analysis and applies it to the Aimsun mesoscopic model. The paper argues that sensitivity analysis is crucial for the best use of the traffic simulation models while also acknowledging
Punzo, V., PUNZO, VINCENZO, J. Perarnau, J. Casas, Perarnau i Codina, Josep, Montanino, Marcello, Casas Vilaró, Jordi, Ciuffo, Biagio   +7 more
core  

Uncertainty and sensitivity in global carbon cycle modelling. [PDF]

, 1998
This paper summarises the results obtained from a stochastic sensitivity study in the area of global carbon cycle modelling. In particular, it outlines how Monte Carlo Simulation (MCS) techniques and associated Generalised Sensitivity Analysis (GSA) have
Young, Peter C., Parkinson, Stuart
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Sensitivity of Pareto Solutions in Multiobjective Optimization. [PDF]

The paper presents a sensitivity analysis of Pareto solutions on the basis of the Karush-Kuhn-Tucker (KKT) necessary conditions applied to nonlinear multiobjective programs (MOP) continuously depending on a parameter.
Balbás, Alejandro, Jiménez Guerra, Pedro, Galperin, Effim   +2 more
core  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source