Results 91 to 100 of about 913,957 (308)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Sensitivity of building zones to potential global warming

, 2009
As global warming entails new conditions for the built environment, the thermal and energy performance of existing buildings, which are designed based on current weather data, may become unclear and remain a great concern.
Guan, Lisa
core   +1 more source

The use of a formal sensitivity analysis on epidemic models with immune protection from maternally acquired antibodies [PDF]

, 2011
This paper considers the outcome of a formal sensitivity analysis on a series of epidemic model structures developed to study the population level effects of maternal antibodies.
Chapman, James D., Chappell, M. J. (Michael J.), Evans, Neil D.   +2 more
core   +1 more source

Peshmelba v2.0 code for global sensitivity analysis

, 2022
PESHMELBA Simulation code for "the paper How to perform global sensitivity analysis of a catchment-scale, distributed pesticide transfer model ? Application to the PESHMELBA model.", Emilie Rouzies, Claire Lauvernet, Bruno Sudret, and Arthur Vidard.
LAUVERNET, CLAIRE, ROUZIES, EMILIE
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Making global sensitivity analysis feasible using neural network surrogates

Data-Centric Engineering
How can we make global sensitivity analysis accessible and viable for engineering practice? In this translation article, we present a methodology to enable sensitivity analysis for structural and geotechnical engineering for built environment design and ...
Gihan Weerasinghe, Ramaseshan Kannan, Samila Bandara   +2 more
doaj   +1 more source

Sensitivity Maps in Environmental Impact Studies

, 2014
Environmental Sensitivity is closely linked to the concepts of reception or absorption recovery that have environmental components such capabilities must be addressed in a holistic and integrated for analysis of constructive alternatives to incorporate
Virgilio NAAez
core  

Comparing two sensitivity analysis approaches for two scenarios with a spatially explicit rural agent-based model

, 2014
In this paper two sensitivity analysis approaches are applied for scenario analysis in a spatially explicit rural agent-based simulation. The simulation aims to assess the socioeconomic and ecological impacts of agricultural policy interventions, market ...
Heijman, W.J.M., Verwaart, T., Heijman, W., Schouten, M.A.H.   +3 more
core   +1 more source

Time-varying global sensitivity analysis software

, 2020
This second release contains the updated code for the final submission of "Global sensitivity analysis informed model reduction and selection applied to a Valsalva maneuver model.
ebenjaminrandall
core   +1 more source