Results 71 to 80 of about 2,456,167 (285)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Global Sensitivity Analysis in Physiological Systems
Applied Mathematics, 2020 Pharmacokinetic models are mathematical models which provide insights into the interaction of chemicals with biological processes. During recent decades, these models have become central of attention in industry that caused to do a lot of efforts to make them more accurate.
Tahmineh Azizi, Robert Mugabi
openaire +2 more sources
Global Dynamics and Sensitivity Analysis of a Vector-Host-Reservoir Model
Sultan Qaboos University Journal for Science, 2016 The role of animal reservoir in the disease dynamics is not yet properly studied. In the present investigation a mathematical model of a vector-host-reservoir is proposed and analyzed to observe the global dynamics of the disease.
Ibrahim M. ELmojtaba +2 more
doaj +1 more source
Local sensitivity analysis for the Cucker-Smale model with random inputs
, 2017 We present pathwise flocking dynamics and local sensitivity analysis for the Cucker-Smale(C-S) model with random communications and initial data. For the deterministic communications, it is well known that the C-S model can model emergent local and ...
Ha, Seung-Yeal, Jin, Shi
core +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Towards global sensitivity analysis of large-scale flood loss models [PDF]
Natural Hazards and Earth System SciencesFlood loss models are increasingly used in the (re)insurance sector to inform a range of financial decisions, and more broadly in research and policy analysis to understand present-day and future flood risk trends.
F. Pianosi +9 more
doaj +1 more source
Parameter sensitivity analysis for different complexity land surface models using multicriteria methods [PDF]
, 2006 A multicriteria algorithm, the MultiObjective Generalized Sensitivity Analysis (MOGSA), was used to investigate the parameter sensitivity of five different land surface models with increasing levels of complexity in the physical representation of the ...
Bastidas, LA +4 more
core +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source