Results 81 to 90 of about 913,957 (308)
Sensitivity Analysis: An Operational Picture
, 2023 Modeling is crucial to understand the behavior of environmental systems. A deeper comprehension of a model can be aided by global sensitivity analysis (GSA).
Dell'Oca, Aronne +3 more
core +1 more source
Discrepancy Measures for Global Sensitivity Analysis
TechnometricsWhile sensitivity analysis improves the transparency and reliability of mathematical models, its uptake by modelers is still scarce. This is partially explained by its technical requirements, which may be hard to understand and implement by the nonspecialist. Here we propose a sensitivity analysis approach based on the concept of discrepancy that is as
Arnald Puy +2 more
openaire +2 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Global sensitivity analysis of parameter uncertainty in landscape evolution models [PDF]
Geoscientific Model Development, 2018 The evaluation and verification of landscape evolution models (LEMs) has long been limited by a lack of suitable observational data and statistical measures which can fully capture the complexity of landscape changes.
C. J. Skinner +4 more
doaj +1 more source
A combined sensitivity analysis and kriging surrogate modeling for early validation of health indicators [PDF]
, 2014 To increase the dependability of complex systems, one solution is to assess their state of health continuously through the monitoring of variables sensitive to potential degradation modes. When computed in an operating environment, these variables, known
MECHBAL, Nazih +2 more
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Global Sensitivity Analysis applied to Total Energy Use in Buildings
, 2012 The work presented in this paper has been carried out in the frame of the IEA-ECBCS Annex 53 project: “Total Energy Use in Buildings: Analysis and evaluation methods”.
Ruiz Flores, Roberto +3 more
core
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Airfoil Optimization and Analysis Using Global Sensitivity Analysis and Generative Design
AerospaceThis research investigates the optimization of airfoil design for fixed-wing drones, aiming to enhance aerodynamic efficiency and reduce drag. The research employs Kulfan CST and Bézier surface parameterization methods combined with global sensitivity ...
Pablo Rouco +3 more
doaj +1 more source