Results 41 to 50 of about 782,077 (262)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Global well-posedness of damped multidimensional generalized Boussinesq equations

open access: yesElectronic Journal of Differential Equations, 2015
We study the Cauchy problem for a sixth-order Boussinesq equations with the generalized source term and damping term. By using Galerkin approximations and potential well methods, we prove the existence of a global weak solution. Furthermore, we study
Yi Niu, Xiuyan Peng, Mingyou Zhang
doaj  

Biosimilars – Global issues, national solutions

open access: yesBiologicals, 2011
Biotechnology derived medicinal products are presently the best characterized biologicals with considerable production and clinical experience, and have revolutionized the treatment of some of the most difficult-to-treat diseases, prolonging and improving the quality of life and patient care.
Knezevic, Ivana, Griffiths, Elwyn
openaire   +2 more sources

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

A hyperbolic-parabolic system arising in pulse combustion: existence of solutions for the linearized problem

open access: yesElectronic Journal of Differential Equations, 2013
A mixed hyperbolic-parabolic system is derived for a lumped parameter continuum model of pulse combustion. For a regularized version of the initial-boundary value problem for an associated linear system, with time-dependent boundary conditions ...
Olga Terlyga   +2 more
doaj  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Nonexistence of non-trivial global weak solutions for higher-order nonlinear Schrodinger equations

open access: yesElectronic Journal of Differential Equations, 2015
We study the initial-value problem for the higher-order nonlinear Schrodinger equation $$ i\partial_{t}u-(-\Delta)^{m}u=\lambda| u|^{p}, $$ subject to the initial data $$ u(x,0)=f(x), $$ where $u=u(x,t)\in\mathbb{C}$ is a complex-valued function,
Abderrazak Nabti
doaj  

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

open access: yesFEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López   +2 more
wiley   +1 more source

A Fujita-type theorem for a multitime evolutionary p-Laplace inequality in the Heisenberg group

open access: yesElectronic Journal of Differential Equations, 2016
A nonexistence result of global nontrivial positive weak solutions to a multitime evolutionary p-Laplace differential inequality in the Heisenberg group is obtained. Our technique of proof is based on the test function method.
Mohamed Jleli   +2 more
doaj  

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