Results 91 to 100 of about 2,378,174 (337)

Global dynamics of an age-structured malaria model with prevention

Mathematical Biosciences and Engineering, 2019
In this paper, we formulate a new age-structured malaria model, which incorporates the age of prevention period of susceptible people, the age of latent period of human and the age of latent period of female Anopheles mosquitoes.
Zhong-Kai Guo , Hai-Feng Huo, Hong Xiang
doaj   +1 more source

On the General Ericksen-Leslie System: Parodi's Relation, Well-posedness and Stability

, 2012
In this paper we investigate the role of Parodi's relation in the well-posedness and stability of the general Ericksen-Leslie system modeling nematic liquid crystal flows.
C. Liu, C. Truesdell, Chun Liu, F. Alouges, F. Leslie, F. Leslie, F.-H. Lin, F.-H. Lin, F.-H. Lin, F.-H. Lin, F.-H. Lin, FH. Lin, G. Jeffery, H. Sun, H. Wu, H. Wu, Hao Wu, J. Ericksen, J. Ericksen, J. Ericksen, J. Ericksen, J. Serrin, J. Zhang, L. Onsager, L. Onsager, L. Onsager, L. Simon, M. Biot, M. Grasselli, M. Gurtin, O. Parodi, P. Currie, P. Currie, P. Currie, P. Currie, P. Lin, P. Mazur, P.G. Gennes de, R.G. Larson, X. Xu, Xiang Xu, Y. Hyon, Y.M. Chen   +42 more
core   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Stabilizing Quantum States by Constructive Design of Open Quantum Dynamics

, 2010
Based on recent work on the asymptotic behavior of controlled quantum Markovian dynamics, we show that any generic quantum state can be stabilized by devising constructively a simple Lindblad-GKS generator that can achieve global asymptotic stability at ...
Schirmer, Sophie G., Ticozzi, Francesco, Wang, Xiaoting   +2 more
core   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Sensitivity analysis of a mathematical model for malaria transmission accounting for infected ignorant humans and relapse dynamics

Frontiers in Applied Mathematics and Statistics
This article presents and analyzes a deterministic model for malaria transmission that incorporates infected individuals who are unaware of their infectious status (ignorant infected humans) and accounts for relapse dynamics.
Getahun Tadesse Haile, Purnachandra Rao Koya, Fekadu Mosisa Legesse   +2 more
doaj   +1 more source

Stability of the global attractor under Markov-Wasserstein noise [PDF]

, 2011
We develop a "weak Wa\.zewski principle" for discrete and continuous time dynamical systems on metric spaces having a weaker topology to show that attractors can be continued in a weak sense.
Kell, Martin
core  

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Global imbalances and financial stability [PDF]

Much of the policy debate in coming years will hinge on two questions: have global imbalances contributed to the financial crisis? Is a reduction in global imbalances a prerequisite to ensuring global financial stability?
Noyer, C.
core