Results 101 to 110 of about 2,378,174 (337)
Molecular Oncology, EarlyView.B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez +17 more
wiley +1 more source
Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence
Molecular Oncology, EarlyView.The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova +18 more
wiley +1 more source
Dynamics of a general model of nonlinear difference equations and its applications to LPA model
Electronic Research ArchiveIn this study, we investigate the qualitative properties of solutions to a general model of difference equations (DEs), which includes the flour beetle model as a particular case.
Wedad Albalawi +2 more
doaj +1 more source
Molecular Oncology, EarlyView.This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh +8 more
wiley +1 more source
Molecular Oncology, EarlyView.The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song +11 more
wiley +1 more source
Lyapunov functions for tuberculosis models with fast and slow progression
Mathematical Biosciences and Engineering, 2006 The spread of tuberculosis is studied through two models whichinclude fast and slow progression to the infected class. For each model, Lyapunovfunctions are used to show that when the basic reproduction numberis less than or equal to one, the disease ...
C. Connell Mccluskey
doaj +1 more source
Molecular Oncology, EarlyView.In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton +17 more
wiley +1 more source
Impact of heterogeneity on the dynamics of an SEIR epidemic model
Mathematical Biosciences and Engineering, 2012 An SEIR epidemic model with an arbitrarily distributed exposed stage is revisited to study the impact of heterogeneity on the spread of infectious diseases.
Zhisheng Shuai, P. van den Driessche
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau +9 more
wiley +1 more source
Modelling the effect of immigration on drinking behaviour
Journal of Biological Dynamics, 2017 A drinking model with immigration is constructed. For the model with problem drinking immigration, the model admits only one problem drinking equilibrium.
Hong Xiang +2 more
doaj +1 more source