Results 101 to 110 of about 9,926,522 (389)
The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity
FEBS Letters, EarlyView.The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
New global stability estimates for monochromatic inverse acoustic scattering
, 2012 We give new global stability estimates for monochromatic inverse acoustic scattering. These estimates essentially improve estimates of [P. Hahner, T. Hohage, SIAM J. Math.
Alexeenko N. V. +12 more
core +2 more sources
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Global stability of an age-structured epidemic model with general Lyapunov functional
Mathematical Biosciences and Engineering, 2019 In this paper, we focus on the study of the dynamics of a certain age structured epidemic model. Our aim is to investigate the proposed model, which is based on the classical SIR epidemic model, with a general class of nonlinear incidence rate with some ...
Abdennasser Chekroun +3 more
doaj +1 more source
Global stability and optimal control for a tuberculosis model with vaccination and treatment
, 2016 We formulate a mathematical model to explore the impact of vaccination and treatment on the transmission dynamics of tuberculosis (TB). We develop a technique to prove that the basic reproduction number is the threshold of global stability of the ...
Yali Yang +4 more
semanticscholar +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Global dynamics of an age-structured malaria model with prevention
Mathematical Biosciences and Engineering, 2019 In this paper, we formulate a new age-structured malaria model, which incorporates the age of prevention period of susceptible people, the age of latent period of human and the age of latent period of female Anopheles mosquitoes.
Zhong-Kai Guo , Hai-Feng Huo, Hong Xiang
doaj +1 more source
Stability of the global attractor under Markov-Wasserstein noise [PDF]
, 2011 We develop a "weak Wa\.zewski principle" for discrete and continuous time dynamical systems on metric spaces having a weaker topology to show that attractors can be continued in a weak sense.
Kell, Martin
core
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source