Results 121 to 130 of about 10,867,243 (338)

Reform of the Global Financial Architecture [PDF]

This paper examines the implications of the global financial crisis of 2007-10 for reform of the global financial architecture, in particular the International Monetary Fund and the Financial Stability Board and their interaction.
Edwin M. Truman, Garry J. Schinasi
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Emerging Infectious Diseases: Threats to Human Health and Global Stability

PLoS Pathogens, 2013
The inevitable, but unpredictable, appearance of new infectious diseases has been recognized for millennia, well before the discovery of causative infectious agents.
D. Morens, A. Fauci
semanticscholar   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Stability analysis of an eco-epidemiological model incorporating a prey refuge

Nonlinear Analysis, 2010
The present paper deals with the problem of a predator-prey model incorporating a prey refuge with disease in the prey-population. We assume the predator population will prefer only infected population for their diet as those are more vulnerable ...
A. K. Pal, G. P. Samanta
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Density Dependent Predator Death Prevalence Chaos in a Tri-trophic Food Chain Model

Nonlinear Analysis, 2008
Ecological systems have all the properties to produce chaotic dynamics. To predict the chaotic behavior in an ecological system and its possible control mechanism is interesting.
M. Bandyopadhyay, S. Chatterjee, S. Chakraborty, J. Chattopadhyay   +3 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Sensitivity analysis of a mathematical model for malaria transmission accounting for infected ignorant humans and relapse dynamics

Frontiers in Applied Mathematics and Statistics
This article presents and analyzes a deterministic model for malaria transmission that incorporates infected individuals who are unaware of their infectious status (ignorant infected humans) and accounts for relapse dynamics.
Getahun Tadesse Haile, Purnachandra Rao Koya, Fekadu Mosisa Legesse   +2 more
doaj   +1 more source

Stability analysis for coupled systems with time-varying coupling structure

Advances in Difference Equations, 2017
The stability of coupled systems with time-varying coupling structure (CSTCS) is considered in this paper. The graph-theoretic method on a digraph with constant weight has been successfully generalized into a digraph with time-varying weight. In addition,
Jiqiang Feng, Xiaojia Luan
doaj   +1 more source