Results 81 to 90 of about 9,312,203 (384)

The effect of PrEP uptake and adherence on the spread of HIV in the presence of casual and long-term partnerships

open access: yesMathematical Biosciences and Engineering, 2022
A model with both casual and long-term partnerships is considered with respect to the impact of a pre-exposure prophylaxis (PrEP) on the spread of HIV. We consider the effect of the effectiveness of PrEP, the rate that susceptible individuals choose to ...
S. J. Gutowska   +2 more
doaj   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

open access: yesFEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp   +5 more
wiley   +1 more source

Restrictions and Stability of Time-Delayed Dynamical Networks

open access: yes, 2012
This paper deals with the global stability of time-delayed dynamical networks. We show that for a time-delayed dynamical network with non-distributed delays the network and the corresponding non-delayed network are both either globally stable or unstable.
Afraimovich V   +12 more
core   +1 more source

Global dynamics of a modified Leslie-Gower predator-prey model with Beddington-DeAngelis functional response and prey-taxis

open access: yesElectronic Research Archive, 2022
In this paper, our purpose is to discuss the global dynamics of a modified Leslie-Gower predator-prey model with Beddington-DeAngelis functional response and prey-taxis under homogeneous Neumann boundary conditions.
Jialu Tian, Ping Liu
doaj   +1 more source

Global stability and optimal control for a tuberculosis model with vaccination and treatment

open access: yes, 2016
We formulate a mathematical model to explore the impact of vaccination and treatment on the transmission dynamics of tuberculosis (TB). We develop a technique to prove that the basic reproduction number is the threshold of global stability of the ...
Yali Yang   +4 more
semanticscholar   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

open access: yesFEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez   +17 more
wiley   +1 more source

Mathematical Analysis of a Prey–Predator System: An Adaptive Back-Stepping Control and Stochastic Approach

open access: yesMathematical and Computational Applications, 2019
In this paper, stochastic analysis of a diseased prey⁻predator system involving adaptive back-stepping control is studied. The system was investigated for its dynamical behaviours, such as boundedness and local stability analysis.
Kalyan Das   +3 more
doaj   +1 more source

Threshold dynamics of a viral infection model with defectively infected cells

open access: yesMathematical Biosciences and Engineering, 2022
In this paper, we investigate the global dynamics of a viral infection model with defectively infected cells. The explicit expression of the basic reproduction number of virus is obtained by using the next generation matrix approach, where each term has ...
Jianquan Li, Xiaoyu Huo , Yuming Chen
doaj   +1 more source

Global stability of fractional SIR epidemic model

open access: yes, 2017
In this work, we prove the global stability of endemic and free disease equilibrium points of the Fractional SIR model using comparison theory of fractional differential inequality and fractional La-Salle invariance principle for fractional differential ...
J. P. C. D. Santos   +2 more
semanticscholar   +1 more source

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

open access: yesFEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää   +2 more
wiley   +1 more source

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