Results 91 to 100 of about 537,238 (257)

Blood RNA Biomarker Signatures for Early Diagnosis and Prognosis in Ischemic and Hemorrhagic Stroke: The IBIS‐CT1 Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the expression of nine blood RNA biomarkers in a clinical trial based on genes previously identified in an experimental monkey model of stroke for diagnosis feasibility and prognostication. Methods IBIS‐CT1 was a prospective longitudinal study enrolling patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH ...
Salomé Retailleau, Marie Bruguet, Irina Viakhireva‐Dovganyuk, François‐Mathias Merrien, Denis Marechal, Aurore Jourdain, Philippe Goas, Jordan Coris, Julien Asselineau, Maëlys Consigny, Gérald Le Gac, Serge Timsit   +11 more
wiley   +1 more source

Trends in Mechanical Intestinal Obstruction: A 30-Year Comparative Analysis Between Developing and Developed Nations

Annals of Global Health
Background: Mechanical intestinal obstruction (MIO) remains a global surgical emergency with significant morbidity and mortality. While prior studies suggest divergent etiological patterns between developed and developing nations, recent trends and ...
Abdel Rahman Al Manasra, Alyaman Mohammad, Hamzeh Alsamarah, Leen Alshobaki, Shefaa Alenezi, Ula Altorman, Tameem Shotar, Salma Alrousan, Anas Aljaiuossi   +8 more
doaj   +1 more source

Temporal Interference Stimulation of Centromedian‐Parafascicular Complex in Disorders of Consciousness: A Pilot Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Treatment of disorders of consciousness (DoC) remains a major clinical challenge, and noninvasive, targeted modulation of deep brain structures has emerged as a promising therapeutic strategy. We aimed to evaluate the feasibility/safety and preliminary effects of thalamic temporal interference stimulation (TIS) targeting centromedian‐
Gengyao Hu, Changgeng Song, Dianwei Wu, Xiaoqian Niu, Jianmin Hao, Lijuan Liu, Xiaogang Kang, Wen Jiang   +7 more
wiley   +1 more source

Osteonecrosis in sickle cell disease: Contemporary orthopaedic practice and outcomes across African healthcare settings

SICOT-J
Background: Osteonecrosis is a disabling complication of sickle cell disease (SCD), with a disproportionate burden in Africa, where healthcare resources are limited.
Oladeji Emmanuel Olusola, Olayode Oluwatobi, Zubair Abdulahi, Ipomai Vernon, Olayinka Oluwafemi, Okonkwo Patrick, Omerenma Onyeka, Okhifun Gregory, Obakponovwe Oghofori   +8 more
doaj   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

Benefits and Drawbacks of Teleneurosurgery in Low- and Middle-Income Countries: A Scoping Review

Acta Neurologica Taiwanica
Telemedicine is an emerging medical technology that allows us to bridge the gap between remote healthcare access and resource provision. Low- to middle-income countries (LMICs), which would benefit greatly from this emerging technology, also face hurdles
Minahil Iman Janjua, Shanza Abbasi, Amna Idrees, Eesha Yaqoob, Nicola Montemurro, Bipin Chaurasia, Saad Javed   +6 more
doaj   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Bidirectional needs assessment of otolaryngology–head and neck surgery short‐term surgical trips in Zimbabwe

Laryngoscope Investigative Otolaryngology
Objectives To describe findings from an otolaryngology‐specific needs assessment tool in Zimbabwe. Methods Surveys were developed and shared with Low‐Middle Income Country (LMIC) hosting institutions in Zimbabwe and to High‐Income Country surgical trip ...
Katerina J. Green, Naboth Matinhira, Amiti Jain, Priya Arya, Dontre' M. Douse, Titus Dzongodza, Clemence Chidziva, Joshua P. Wiedermann   +7 more
doaj   +1 more source

Arterial Spin‐Labeling MRI at the Cortical‐CSF Interface: A Novel Biomarker in Alzheimer Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background/Objective Arterial spin‐labeling (ASL) MRI can measure perfusion signal adjacent to CSF spaces and may provide information regarding CSF‐adjacent water transport physiology. We developed an automated pipeline to extract cortical‐CSF interface (IF) perfusion for comparison between Alzheimer disease (AD) and cognitively normal ...
Mona Asghariahmadabad, Pouya Metanat, Michael Thomas, Luke W. Bonham, Tyson Lam, Mehmet Kurt, Hong Nguyen, Tara Ellingson, Mauro Zucchelli, Stefano Casagranda, Quin Lu, Andreas M. Rauschecker, Leo Sugrue, Luis E. Savastano, Christopher P. Hess, Kamalini Ranasinghe, S. Andrew Josephson, Bruce L. Miller, Jennifer S. Yokoyama, Gil D. Rabinovici, Peter A. Ljubenkov, Lawren VandeVrede, Kambiz Nael   +22 more
wiley   +1 more source

Successful Digital Replantation in a Resource-Limited Kenyan Hospital: A Case Report and Discussion

Surgeries
Replantation of an amputated finger is a complex microsurgical procedure that is rarely attempted in low-resource settings due to limited infrastructure and expertise.
Alfio Luca Costa, Luca Folini, Alvise Montanari, Franco Bassetto   +3 more
doaj   +1 more source