Results 81 to 90 of about 7,406,094 (340)

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Achieving Surgical, Obstetric, Trauma, and Anesthesia (SOTA) care for all in South Asia

Frontiers in Public Health
South Asia is a demographically crucial, economically aspiring, and socio-culturally diverse region in the world. The region contributes to a large burden of surgically-treatable disease conditions.
Siddhesh Zadey, Siddhesh Zadey, Siddhesh Zadey, Siddhesh Zadey, Shirish Rao, Shirish Rao, Shirish Rao, Isha Gondi, Isha Gondi, Natalie Sheneman, Chaitrali Patil, Chaitrali Patil, Anveshi Nayan, Anveshi Nayan, Himanshu Iyer, Arti Raj Kumar, Arun Prasad, G. Allen Finley, Chellapuram Raja Krishna Prasad, Chintamani, Dhananjaya Sharma, Dhruva Ghosh, Gnanaraj Jesudian, Gnanaraj Jesudian, Gnanaraj Jesudian, Gnanaraj Jesudian, Irum Fatima, Jogi Pattisapu, Justin Sangwook Ko, Lovenish Bains, Lovenish Bains, Mashal Shah, Mohammed Shadrul Alam, Mohammed Shadrul Alam, Mohammed Shadrul Alam, Mohammed Shadrul Alam, Narmada Hadigal, Narmada Hadigal, Naveen Malhotra, Nilmini Wijesuriya, Prateek Shukla, Sadaf Khan, Sunil Pandya, Tariq Khan, Tashi Tenzin, Tashi Tenzin, Tashi Tenzin, Venkat Raja Hadiga, Daniel Peterson   +48 more
doaj   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Disseminating technology in global surgery [PDF]

British Journal of Surgery, 2019
Abstract Background Effective dissemination of technology in global surgery is vital to realize universal health coverage by 2030. Challenges include a lack of human resource, infrastructure and finance.
Bolton, WS, Aruparayil, N, Quyn, A, Scott, J, Wood, A, Bundu, I, Gnanaraj, J, Brown, JM, Jayne, DG   +8 more
openaire   +3 more sources

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Strengthening Reconstructive Urology with an Aim for Capacity-Building in a Low-Middle-Income Country: A Multi-Institutional Global Surgery Collaboration Initial Report

Société Internationale d’Urologie Journal
Background/Objectives: Reconstructive urology is critically underrepresented in global surgery initiatives, despite its essential role in managing congenital and acquired urogenital conditions.
Michael E. Chua, R. Christopher Doiron, Kurt McCammon, Ellen C. Chong, Marie Carmela Lapitan, Joel Patrick Aldana, Diosdado Limjoco, Josefino Castillo, Dennis Serrano, Manuel See   +9 more
doaj   +1 more source

Delphi prioritization and development of global surgery guidelines for the prevention of surgical‐site infection

British Journal of Surgery, 2020
Most clinical guidelines are developed by high‐income country institutions with little consideration given to either the evidence base for interventions in low‐ and middle‐income countries (LMICs), or the specific challenges LMIC health systems may face ...
Dmitri Adewale Francis Atindaana Adesoji Sohini Dhruva Ja Nepogodiev Adisa Abantanga Ademuyiwa Chakrabortee , D. Nepogodiev, A. Adisa, F. Abantanga, A. Ademuyiwa, S. Chakrabortee, Dhruva Ghosh, J. Glasbey, M. C. Lapitan, I. Lawani, M. Maimbo, Rachel Moore, D. Morton, F. Ntirenganya, A. Qureshi, A. Ramos-De la Medina, S. Tabiri, Thomas D. Pinkney, A. Bhangu, A. Adenekan, A. Adewunmi, M. Aguilera, B. Biccard, P. Brocklehurst, Ainhoa Costa, P. Cotton, J. Davies, T. Drake, O. Garden, Dhruva Ghosh, P. Haque, E. Harrison, J. Ingabire, S. Knight, Richard Lilford, Janet Martin, L. Miguelena, R. Mittal, Vanessa Msosa, S. Naqi, J. Olory-Togbé, O. Omar, Thomas D. Pinkney, H. Salem, Martin D. Smith, S. Sundar, E. Yenli, R. Yepez, E. Zoumènou, Conor S. Jones, C. Kajombo, S. Lawday, M. Nyundo, A. R. la Medina, Dione Parreño-Sacdalan   +54 more
semanticscholar   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Examining the Obstacles to Timely Otolaryngology Care in Ethiopia and Zimbabwe: A Comparative Analysis

OTO Open
This study compares delays in otolaryngologic care between patients in Mekelle, Ethiopia and Harare, Zimbabwe using the Three Delays model. Patient surveys conducted among 46 patients in Zimbabwe during October 2022 and 105 patients in Ethiopia during ...
Daniel G. Eyassu, Estephania Candelo, Katerina J. Green, Katherine P. Wallerius, Brhanu H. Asgedom, Joshua P. Wiedermann   +5 more
doaj   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source