Results 101 to 110 of about 749,476 (345)

Trade crisis and recovery : restructuring of global value chains [PDF]

open access: yes
The recent large and rapid slowdown in economic activity has resulted in even larger and more rapid declines in international trade. As world trade is set to rebound, this paper addresses three questions: (i) Will trade volumes rebound in a symmetric ...
Milberg, William, Winkler, Deborah
core  

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

The Role of Services in Global Value Chains [PDF]

open access: yesVestnik of Vitebsk State Technological University, 2017
For the past decades international production, trade and investments have been increasingly organized within global value chains (GVCs), where different stages of production process are allocated across different countries.
Natalya Gluhova
doaj  

Global Value Chains, Technology Transfer and Local Firm Upgrading in Non-OECD Countries [PDF]

open access: yes
The productivity and competitiveness of local firms in non-OECD countries depends as much on technological capacities and successful upgrading as in industrialized countries.
Juliane Brach, Robert Kappel
core  

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

open access: yesMolecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li   +10 more
wiley   +1 more source

The Relationship Between Global Value Chains and Productivity [PDF]

open access: yesInternational Productivity Monitor, 2017
We review the evidence linking Global Value Chains (GVCs) and productivity. GVCs are a key feature of the world economy, with production increasingly fragmented across borders.
Chiara Criscuolo, Jonathan Timmis
doaj  

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