Results 111 to 120 of about 749,476 (345)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Multinational firms, global value chains and the organization of technology transfer [PDF]

This paper combines insights from different streams of literature to develop a more comprehensive framework for the analysis of technology transfer via value chain relationships. We integrate the existing literature in three ways.
Antonello Zanfei, Federica Saliola
core  

Tourism global value chains and Africa

, 2017
As Africa continues to attract record numbers of international arrivals, there are industry undercurrents that influence the continent's participation in tourism value chains.
Daly, Jack, Gereffi, Gary
core   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

OPPORTUNITIES RUSSIA GETS IN CASE OF PARTICIPATION IN THE SYSTEM OF THE GLOBAL VALUE CHAINS IN THE ENERGY SPHERE: SOUTH KOREA’S CASE

Мир новой экономики, 2018
This article aims at analyzing Russia’s potential and opportunities in case of participation in global value chains. After making a theoretical analysis of global value chains functioning authors conclude that Russian state policy should be focused on ...
ALEXANDER VITALEVICH Larionov, KSENIA IGOREVNA Andryushchenko   +1 more
doaj  

Basics of Optimization Strategy for Integrating Space Industry Technology Package Into Global Value Chains

Economics and Business, 2017
The article deals with basic characteristics and fundamentals of innovation management of global value chains and considerations on the example of space industry based on the factor of interaction in the creation of new products in global value chains ...
Omelyanenko Vitaliy
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Double-edged sword of technological progress to climate change depends on positioning in global value chains. [PDF]

PNAS Nexus, 2023
Liang S, Zhong Q, Zhou H, Liao Y, You J, Meng J, Feng C, Lin C.   +7 more
europepmc   +1 more source

Organic farming and fair trade in developing country as a new agribusiness paradigm: Evidence from Mali [PDF]

Organic farming and fair trade certified chains have emerged in West-Africa since the 1990s in answer to new alternative markets in developed countries.
Bastiaensen, Johan, Dessein, Joost, Lauwers, Ludwig H., Sinaba, Famory, Teme, Bino   +4 more
core   +1 more source

Two methodological approaches to the study of production chains in tourism industry [PDF]

, 2007
In this article, two different methodological frameworks are applied to study the production chains in the tourism industry in Andalusia (Spain). Firstly, from a macroeconomic perspective, input-output techniques are used to identify tourism production ...
Romero Luna, Isidoro, Tejada González, Pilar   +1 more
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