Results 81 to 90 of about 511,014 (306)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Economic vitality in a transition to sustainability [PDF]

The good news is that many of the solutions to this extraordinary problem are within reach. Many of the solutions to global warming are not only feasible, they are economically and socially beneficial. While some claim that addressing global warming will
Goodwin, Neva
core   +1 more source

Potential impacts for monitoring sustainability: case study of hollow fiber membrane [PDF]

, 2017
Sustainability level is a new indicator of quality and efficiency for product life cycle. Sustainability should be balanced among Triple Bottom Line (TBL) aspects namely environmental, economic and social elements.
Hemdi, Abdul Rahman, Mahmood, Salwa, Mat Saman, Muhamad Zameri, Zakuan, Norhayati   +3 more
core  

Predicting the global warming potential of agro-ecosystems [PDF]

, 2007
Abstract. Nitrous oxide, carbon dioxide and methane are the main biogenic greenhouse gases (GHG) contributing to the global warming potential (GWP) of agro-ecosystems. Evaluating the impact of agriculture on climate thus requires a capacity to predict the net exchanges of these gases in an integrated manner, as related to environmental conditions and ...
Lehuger, Simon, Gabrielle, Benoit, Larmanou, Eric, Laville, Particia, Cellier, Pierre, Loubet, Benjamin   +5 more
openaire   +6 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

use natural gas consumption in 201Scenarios to decarbonize residential water heating in California [PDF]

, 2017
This paper presents the first detailed long-term stock turnover model to investigate scenarios to decarbonize the residential water heating sector in California, which is currently dominated by natural gas.
Kammen, Daniel M, Raghavan, Shuba V, Wei, Max   +2 more
core  

Climate-Change Impact Potentials as an Alternative to Global Warming Potentials

Environmental Research Letters, 2014
For policy applications, such as for the Kyoto Protocol, the climate-change contributions of different greenhouse gases are usually quantified through their global warming potentials. They are calculated based on the cumulative radiative forcing resulting from a pulse emission of a gas over a specified time period.
openaire   +2 more sources

Quaternary paleoclimatology, neotropical biodiversity, and potential effects of global warming.

Contributions to Science, 2007
[CAT] Els canvis climàtics quaternaris enregistrats a l’hemisferi nord també han afectat la regió neotropical i han contribuït a definirne els patrons actuals de biodiversitat. Els estudis moleculars de DNA que s’han dut a terme en espècies neotropicals actuals mostren una acceleració significativa de les taxes d’especiació en els darrers 5 milions d ...
Rull del Castillo, Valentí, Vegas Vilarrúbia, Teresa Elena, Nogué, S., Montoya Romo, Encarnación, Cañellas Boltà, Núria, Lara, Arantza   +5 more
openaire   +5 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source