Results 81 to 90 of about 81,592 (259)

Future projection of tropical cyclone genesis in the Western North pacific using high-resolution GCMs and genesis potential indices

Weather and Climate Extremes
The study employed high-resolution atmospheric general circulation models (AGCM) to simulate tropical cyclones (TCs) and evaluated two TC genesis potential indices in reflecting projected TC changes in the western North Pacific (WNP) under a warming ...
Li-Peng Hsiao, Huang-Hsiung Hsu, Ruo-Ya Hung   +2 more
doaj   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Effect of C2H2F4/CF4O with low global warming potentials on SiNx etching as a CHF3 replacement

Scientific Reports
As the size of the device continues to decrease due to the increasing demand for faster processing speed and lower power consumption in semiconductor integrated circuit device technology, the double patterning process is widely used.
Kyung Lim Kim, Jong Woo Hong, Young Woo Jeon, Jun Won Jeong, Chan Ho Kim, Hyeong Joon Eoh, Sung Hyun Kim, Jong Soon Park, Nam Il Cho, Jung Hun Kwak, Yongil Kim, Geun Young Yeom   +11 more
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Global warming potential for CF[sub 4]

, 1992
With sufficient emissions, fluorinated gases such as CF[sub 4] could contribute significantly to the concerns about global warming because they are greenhouse gases, are chemically very inert, and have long accumulation lifetimes in the atmosphere. At this time, the only significant known source of CF[sub 4] is primary aluminum smelting (Abrahamson ...
D Wuebbles, A Grossman
openaire   +2 more sources

Impact of Ocean Warming on Tropical Cyclone Size and Its Destructiveness

Scientific Reports, 2017
The response of tropical cyclone (TC) destructive potential to global warming is an open issue. A number of previous studies have ignored the effect of TC size change in the context of global warming, which resulted in a significant underestimation of ...
Yuan Sun, Zhong Zhong, Tim Li, Lan Yi, Yijia Hu, Hongchao Wan, Haishan Chen, Qianfeng Liao, Chen Ma, Qihua Li   +9 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Global wheat planting suitability under the 1.5°C and 2°C warming targets

Frontiers in Plant Science
The potential distribution of crops will be impacted by climate change, but there is limited research on potential wheat distributions under specific global warming targets.
Xi Guo, Puying Zhang, Yaojie Yue
doaj   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source