Results 81 to 90 of about 81,899 (259)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Future projection of tropical cyclone genesis in the Western North pacific using high-resolution GCMs and genesis potential indices

Weather and Climate Extremes
The study employed high-resolution atmospheric general circulation models (AGCM) to simulate tropical cyclones (TCs) and evaluated two TC genesis potential indices in reflecting projected TC changes in the western North Pacific (WNP) under a warming ...
Li-Peng Hsiao, Huang-Hsiung Hsu, Ruo-Ya Hung   +2 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Impact of Ocean Warming on Tropical Cyclone Size and Its Destructiveness

Scientific Reports, 2017
The response of tropical cyclone (TC) destructive potential to global warming is an open issue. A number of previous studies have ignored the effect of TC size change in the context of global warming, which resulted in a significant underestimation of ...
Yuan Sun, Zhong Zhong, Tim Li, Lan Yi, Yijia Hu, Hongchao Wan, Haishan Chen, Qianfeng Liao, Chen Ma, Qihua Li   +9 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Effect of C2H2F4/CF4O with low global warming potentials on SiNx etching as a CHF3 replacement

Scientific Reports
As the size of the device continues to decrease due to the increasing demand for faster processing speed and lower power consumption in semiconductor integrated circuit device technology, the double patterning process is widely used.
Kyung Lim Kim, Jong Woo Hong, Young Woo Jeon, Jun Won Jeong, Chan Ho Kim, Hyeong Joon Eoh, Sung Hyun Kim, Jong Soon Park, Nam Il Cho, Jung Hun Kwak, Yongil Kim, Geun Young Yeom   +11 more
doaj   +1 more source

Global warming potential for CF[sub 4]

, 1992
With sufficient emissions, fluorinated gases such as CF[sub 4] could contribute significantly to the concerns about global warming because they are greenhouse gases, are chemically very inert, and have long accumulation lifetimes in the atmosphere. At this time, the only significant known source of CF[sub 4] is primary aluminum smelting (Abrahamson ...
D Wuebbles, A Grossman
openaire   +2 more sources

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source

Global wheat planting suitability under the 1.5°C and 2°C warming targets

Frontiers in Plant Science
The potential distribution of crops will be impacted by climate change, but there is limited research on potential wheat distributions under specific global warming targets.
Xi Guo, Puying Zhang, Yaojie Yue
doaj   +1 more source