Results 161 to 170 of about 358,324 (325)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Explaining the wage gap: Heckscher-Ohlin, economic geography and services availability [PDF]

open access: yes
In the debate on globalisation and wage inequality Heckscher-Ohlin, economic geography and services availability theory has featured prominently. However, a neglected mechanism by which globalisation affects labour market outcomes is through the in ...
Peeters, J., Vaal, A. de
core   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

open access: yesMolecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal   +4 more
wiley   +1 more source

Global research agenda for medical education regulation: findings from a nominal group consensus exercise. [PDF]

open access: yesBMJ Glob Health
Bollela VR   +17 more
europepmc   +1 more source

Globalisation and Social Spending [PDF]

open access: yes
We provide evidence indicating that countries with well-developed social security systems do not necessarily face a trade-off between social spending and competitiveness.
Magdalena Polan, Paul De Grauwe
core  

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

open access: yesMolecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

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