Results 111 to 120 of about 2,062,667 (361)

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

open access: yesMolecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin   +14 more
wiley   +1 more source

Evaluation of an EPID in vivo monitoring system using local and external independent audit measurements

open access: yesJournal of Applied Clinical Medical Physics, Volume 23, Issue 12, December 2022., 2022
Abstract Purpose The aim of this work was to evaluate the SunCHECK PerFRACTION, the software for in vivo monitoring using EPID images. Materials/Methods First, the PerFRACTION ability to detect errors was investigated simulating two situations: (1) variation of LINAC output and (2) variation of the phantom thickness.
Samuel Ramalho Avelino   +3 more
wiley   +1 more source

Method Factors in Democracy Indicators

open access: yesPolitics and Governance, 2018
Method factors represent variance common to indicators from the same data source. Detecting method factors can help uncover systematic bias in data sources.
Martin Elff, Sebastian Ziaja
doaj   +1 more source

On global Okounkov bodies of spherical varieties [PDF]

open access: yesarXiv, 2017
We define and study the global Okounkov moment cone of a projective spherical variety X, generalizing both the global Okounkov body and the moment body of X defined by Kaveh and Khovanskii. Under mild assumptions on X we show that the global Okounkov moment cone of X is rational polyhedral.
arxiv  

Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas   +15 more
wiley   +1 more source

Examining hidden coercion at state borders: why carrier sanctions cannot be justified

open access: yesEthics & Global Politics, 2014
Sanctions placed upon airlines and other operators transporting persons without the required paperwork are called ‘carrier sanctions’. They constitute a key example of how border control mechanisms are currently being outsourced, privatized, delegated ...
Tendayi Bloom, Verena Risse
doaj   +1 more source

Global Challenges, Global Opportunities

open access: yesAnnals of Global Health, 2014
Academia is at an exciting crossroads. The global problems we face are immense, but the good news is we know how to address most of them. Our primary challenge today is not a lack of knowledge but a failure to scale up what we already know works. Some of the skills to implement what we know are medical, many are not.
openaire   +5 more sources

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

open access: yesMolecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park   +6 more
wiley   +1 more source

Clemente Padín: no solo arte correo. De las experiencias inobjetales a la performance

open access: yesBoletín de Arte, 2017
Clemente Padín (1939), artista uruguayo conocido por su activismo en la red de arte correo, trabajó no solo con poesía visual y envíos postales, sino, también, con libros de artista propositivos y performances.
Pablo Santa Olalla
doaj  

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