Results 121 to 130 of about 2,062,667 (361)

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

open access: yesMolecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren   +4 more
wiley   +1 more source

Globalization Report 2018: Who Benefits Most from Globalization? Bertelsmann Policy Brief #2018/02 [PDF]

open access: yes, 2018
There is growing uncertainty in industrialized countries as to whether globalization means more opportunity or more risk. Trump, Brexit and increasing populism are direct consequences of this development.
Jungbluth, Cora   +3 more
core  

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi   +26 more
wiley   +1 more source

Brave New Words: Labour, The Courts and the Canadian Charter of Rights and Freedoms

open access: yesThe Windsor Yearbook of Access to Justice, 2010
In Health Services and Support – Facilities Subsector Bargaining Association v. British Columbia, [2007] 2 S.C.R. 391, the Supreme Court of Canada overturned precedent and concluded “that the grounds advanced in the earlier decisions for the exclusion of
Judy Fudge
doaj   +1 more source

Enhancing patient engagement in cancer research: a focus on patient‐centric approaches to scientific discovery

open access: yesMolecular Oncology, EarlyView.
Patient engagement involves actively including patients in healthcare decisions and research to ensure care and studies align with their needs. This approach improves outcomes, trust, and communication while fostering collaboration between patients and professionals.
Estela Cepeda   +3 more
wiley   +1 more source

DO ELECTIONS SLOW DOWN ECONOMIC GLOBALIZATION PROCESS IN INDIA? IT’S POLITICS STUPID ! [PDF]

open access: yes
I investigate whether timing of the elections impact economic globalization process or not in India. In other words, do elections slowdown economic globalization process?
Vadlamannati, Krishna Chaitanya
core   +4 more sources

Global cooperation for a global pandemic

open access: yesNature Reviews Genetics, 2022
The COVID-19 pandemic has highlighted the challenges and opportunities of our inter-connected world in responding to global crises.
openaire   +2 more sources

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

open access: yesMolecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak   +14 more
wiley   +1 more source

In vitro Effects of Methanol Extracts of Korean Medicinal Fruits (Persimmon, Raspberry, Tomato) on Chicken Lymphocytes, Macrophages, and Tumor Cells

open access: yesThe Journal of Poultry Science, 2009
A variety of fruits have traditionally been used in Asian cultures to enhance resistance to diseases and treat cancers. However, limited information exists on the underlying mechanisms responsible for these effects.
Sung-Hyen Lee   +5 more
doaj   +1 more source

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