Results 141 to 150 of about 85,801 (378)

Globular Cluster Formation in M82

, 2003
We present high resolution mid-infrared (mid-IR; 11.7 and 17.65 micron) maps of the central 400 pc region of the starburst galaxy M82. Seven star forming clusters are identified which together provide ~ 15% of the total mid-IR luminosity of the galaxy ...
Cottrell G., Knodlseder J., Mandushev G., Neininger N., P. Plavchan, S. J. Lipscy, Weliachew L.   +6 more
core   +2 more sources

Comprehensive profiling of lncRNAs and mRNAs enriched in small extracellular vesicles for early noninvasive detection of colorectal cancer: diagnostic panel assembly and extensive validation

Molecular Oncology, EarlyView.
Small extracellular vesicles are a promising source of diagnostic molecules. We conducted a comprehensive study, including transcriptome profiling and RT‐qPCR validation on large cohorts of samples. Diagnostic panels enabling sensitive detection of colorectal cancer and precancerous lesions were established. Some molecules were differentially expressed
Petra Vychytilova‐Faltejskova, Marketa Pavlikova, Lucie Pifkova, Robin Jugas, Tana Machackova, Lenka Radova, Milana Sachlova, Renata Bartosova, Tetiana Samoilenko, Zuzana Feckova, Jana Orlickova, Erika Slamova, Elleni Ponechal Michu, Dagmar Al Tukmachi, Michaela Ruckova, Martina Vodinska, Jan Kotoucek, Tina Catela Ivkovic, Marie Boudna, Lucia Bohovicova, Teodor Stanek, Jana Halamkova, Martin Svoboda, Vladimir Prochazka, Tomas Grolich, Zdenek Kala, Ondrej Slaby   +26 more
wiley   +1 more source

FAST Discovery of Eight Isolated Millisecond Pulsars in NGC 6517

The Astrophysical Journal Letters
We present the discovery of eight isolated millisecond pulsars in globular cluster (GC) NGC 6517 using the Five-hundred-meter Aperture Spherical radio Telescope (FAST).
Dejiang Yin, Li-yun Zhang, Lei Qian, Ralph P. Eatough, Baoda Li, Duncan R. Lorimer, Yinfeng Dai, Yaowei Li, Xingnan Zhang, Minghui Li, Tianhao Su, Yuxiao Wu, Yu Pan, Yujie Lian, Tong Liu, Zhen Yan, Zhichen Pan   +16 more
doaj   +1 more source

Binary Stars in Globular and Open Clusters [PDF]

Symposium - International Astronomical Union, 1980
In erecting the edifice we call science, it is given to some to draw the plans by which the entire effort will be guided, to others to lay the foundation stones on which the rest is built, to another group to place the windows that let in light upon the whole, and to still others to cover the result with the paint that will make it acceptable to the ...
openaire   +2 more sources

The critical role of DNA damage‐inducible transcript 4 (DDIT4) in stemness character of leukemia cells and leukemia initiation

Molecular Oncology, EarlyView.
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li, Zhijie Cao, Haiyan Xing, Zhenya Xue, Wenbing Liu, Jiayuan Chen, Yihan Mei, Runxia Gu, Hui Wei, Shaowei Qiu, Min Wang, Qing Rao, Jianxiang Wang   +12 more
wiley   +1 more source

Modeling Formation of Globular Clusters: Beacons of Galactic Star Formation

, 2010
Modern hydrodynamic simulations of galaxy formation are able to predict accurately the rates and locations of the assembly of giant molecular clouds in early galaxies.
Gnedin, Oleg Y.
core   +1 more source

Globular cluster star classification: Application to M13 [PDF]

Serbian Astronomical Journal, 2013
Starting from recent determination of Fe, O, Na abundances on a restricted sample (N = 67) of halo and thick disk stars, a natural and well motivated selection criterion is defined for the classification globular cluster stars. An application is performed to M13 using a sample (N = 113) for which Fe, O, Na abundances have been recently ...
openaire   +4 more sources

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source