Results 131 to 140 of about 37,443 (293)

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Pregalactic globular cluster formation induced by primordial black holes

Discover Space
Globular clusters are among the oldest known objects in the Universe, yet their formation process remains insufficiently understood. Early work hypothesised that globular clusters formed before galaxies themselves.
Jeremy Mould, Jarrod Hurley
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Spectroscopic Study of Globular and Fuzzy Clusters in Lenticular Galaxy NGC 1023

The Astrophysical Journal
We here report the results from spectroscopic observations of a sample of 26 globular cluster (GC) and 21 faint fuzzy (FF) candidates in the lenticular galaxy NGC 1023 using the 10.4 m Gran Telescopio Canarias.
M. A. López-Santamaría, Y. D. Mayya, Luis Lomelí-Núñez, L. H. Rodríguez-Merino, Jairo A. Alzate, Arianna Cortesi, P. A. Ovando, D. Rosa-González   +7 more
doaj   +1 more source

Functional Connectivity Linked to Cognitive Recovery After Minor Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Patients with minor stroke exhibit slowed processing speed and generalized alterations in functional connectivity involving frontoparietal cortex (FPC). The pattern of connectivity evolves over time. In this study, we examine the relationship of functional connectivity patterns to cognitive performance, to determine ...
Vrishab Commuri, Isabella Dallasta, Ciaran Stone, Sophia Girgenti, Neda Gould, Rafael H. Llinas, Jonathan Z. Simon, Elisabeth Breese Marsh   +7 more
wiley   +1 more source

Spectroscopic Confirmation: Fast Rotators in the Young Clusters NGC 1856 and NGC 1953

The Astrophysical Journal
We present the results of a spectroscopic investigation of two Large Magellanic Cloud globular clusters, NGC 1953 and NGC 1856. Both clusters have similar ages (250 and 300 Myr, respectively). Spectra were recorded with the Michigan/Magellan Fiber System
Paul I. Cristofari, Andrea K. Dupree, Antonino P. Milone, Mario Mateo, Matias Chiarpotti   +4 more
doaj   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Cracking the Relation Between Mass and 1P-star Fraction of Globular Clusters. III. Initial Distributions of In Situ and Ex Situ Clusters

The Astrophysical Journal
Galactic globular clusters consist of two main stellar populations, the pristine (1P) and polluted (2P) stars. The fraction of 1P stars in clusters, F _1P , is a decreasing function of the present-day cluster mass, m _prst . The information about cluster
Geneviève Parmentier
doaj   +1 more source