Results 111 to 120 of about 37,443 (293)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Searching for Pulsars in Globular Clusters with the Fast-folding Algorithm and a New Pulsar Discovered in M13

The Astrophysical Journal
We employed the fast-folding algorithm on L -band globular cluster (GC) observations taken with the Five-hundred-meter Aperture Spherical radio Telescope to search for new pulsars, especially those with a long rotational period.
Yaowei Li, Lin Wang, Lei Qian, Liyun Zhang, Yujie Chen, Dejiang Yin, Baoda Li, Yinfeng Dai, Ralph P. Eatough, Wenze Li, Dongyue Jiang, Xingnan Zhang, Minghui Li, Yujie Lian, Yuxiao Wu, Tong Liu, Kuo Liu, Zhichen Pan   +17 more
doaj   +1 more source

Variable stars in the VVV globular clusters

Astronomy & Astrophysics
Context. High reddening near the Galactic plane hampers observations and proper characterization of the globular clusters (GCs) located toward the inner regions of the Milky Way. Aims. The VISTA Variables in the Vía Láctea (VVV) survey observed the Galactic bulge and adjacent disk for several years, providing multi-epoch, near-infrared images for 41 ...
Javier Alonso-García, Leigh C. Smith, Jason L. Sanders, Dante Minniti, Márcio Catelan, Gonzalo Aravena Rojas, Julio A. Carballo-Bello, José G. Fernández-Trincado, Carlos E. Ferreira Lopes, Elisa R. Garro, Zhen Guo, Maren Hempel, Philip W. Lucas, Daniel Majaess, Roberto K. Saito, A. Katherina Vivas   +15 more
openaire   +2 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Ancient Relic Moderately Metal-rich Bulge Cluster Tonantzintla 2

The Astrophysical Journal Letters
The assembly history of the Galactic bulge is intimately tied to the formation of the proto–Milky Way, yet reconstructing this early phase is difficult because mergers and secular evolution have erased most of its original structure.
Sergio Ortolani, Stefano O. Souza, Domenico Nardiello, Beatriz Barbuy, Eduardo Bica, Bernardo P.L. Ferreira, Cristina Chiappini, José G. Fernández-Trincado, Heitor Ernandes   +8 more
doaj   +1 more source

The inner Galactic globular clusters

EPJ Web of Conferences, 2013
Galactic globular clusters located towards the inner regions of the Milky Way have been historically neglected, mainly due to the difficulties caused by the presence of an elevated extinction by foreground dust, and high field star densities along the ...
Mateo M., Catelan M., Alonso-García J., Minniti D.   +3 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Searching for Variability in the Blue Straggler Star Region of the Globular Cluster NGC 6397

The Astronomical Journal
We studied stellar variability in the subgiant branch and blue straggler stars region of the globular cluster NGC 6397. The aim of this research is to identify and characterize new short-period, low-amplitude variable stars.
T. Cisternas-Araya, C. C. Cortés, S. Villanova, J. A. Ahumada, M. C. Parisi   +4 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

A Novel Technique for Long-term Timing of Redback Millisecond Pulsars

The Astrophysical Journal
We present timing solutions spanning nearly two decades for five redback (RB) systems found in globular clusters (GCs), created using a novel technique that effectively “isolates” the pulsar. By accurately measuring the time of passage through periastron
Kyle A. Corcoran, Scott M. Ransom, Alexandra C. Rosenthal, Megan E. DeCesar, Paulo C. C. Freire, Jason W. T. Hessels, Ryan S. Lynch, Prajwal V. Padmanabh, Ingrid H. Stairs   +8 more
doaj   +1 more source