Results 91 to 100 of about 2,554 (268)

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

A Novel Technique for Long-term Timing of Redback Millisecond Pulsars

The Astrophysical Journal
We present timing solutions spanning nearly two decades for five redback (RB) systems found in globular clusters (GCs), created using a novel technique that effectively “isolates” the pulsar. By accurately measuring the time of passage through periastron
Kyle A. Corcoran, Scott M. Ransom, Alexandra C. Rosenthal, Megan E. DeCesar, Paulo C. C. Freire, Jason W. T. Hessels, Ryan S. Lynch, Prajwal V. Padmanabh, Ingrid H. Stairs   +8 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Mass Distribution of Binary Black Hole Mergers from Young and Old Dense Star Clusters

The Astrophysical Journal
Dense star clusters are thought to contribute significantly to the merger rates of stellar-mass binary black holes (BBHs) detected by the LIGO–Virgo–KAGRA collaboration.
Claire S. Ye, Maya Fishbach, Kyle Kremer, Marta Reina-Campos   +3 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

PHANGS Hubble Space Telescope Treasury Survey: Globular Cluster Systems in 17 Nearby Spiral Galaxies

The Astronomical Journal
We present new catalogs of likely globular clusters (GCs) in 17 nearby spiral galaxies studied as part of the PHANGS Hubble Space Telescope (HST) Treasury Survey.
Matthew Floyd, Rupali Chandar, Bradley C. Whitmore, David A. Thilker, Janice C. Lee, Rachel E. Pauline, Zion L. Thomas, William J. Berschback, Kiana F. Henny, Daniel A. Dale, Ralf S. Klessen, Eva Schinnerer, Kathryn Grasha, Médéric Boquien, Kirsten L. Larson, Sinan Deger, Ashley T. Barnes, Adam K. Leroy, Erik Rosolowsky, Thomas G. Williams, Leonardo Úbeda   +20 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Photometric Analysis of Variable Stars in NGC 6397

The Astronomical Journal
This study investigates a population of low-amplitude, short-period variable stars in the globular cluster NGC 6397, specifically targeting those stars between 11 and 15 mag in the V band.
C.C. Cortés, F. Villarroel, R. Villarroel, S. Villanova, J.A. Ahumada, M.C. Parisi   +5 more
doaj   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source